Skip to main content
OpenTrials
Completed

NCT Number: NCT00716157

Incidence and Patterns of Nausea/Vomiting With Combined Chemotherapy and Radiation

Questionnaire study to observe the incidence and pattern or nausea and vomiting in patients receiving combined chemotherapy and radiation. 83% of patients experience radiation therapy-induced vomiting; significant nausea and vomiting could develop with concurrent chemotherapy despite standard anti-nauseous medication prophylaxis.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Cancer of the Head and Neck Cancer of the Esophagus Cancer of the Lung Digestive System Diseases Digestive System Neoplasms Esophageal Diseases Esophageal Neoplasms Gastro-esophageal Junction Cancer Gastrointestinal Diseases Gastrointestinal Neoplasms Head and Neck Neoplasms Lung Diseases Lung Neoplasms Neoplasms Neoplasms by Site Respiratory Tract Diseases Respiratory Tract Neoplasms Thoracic Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Thomas Jefferson University

Philadelphia, Pennsylvania, 19107, United States

About this study

Questionnaires will be answered daily on a weekly basis during period of radiation and chemotherapy.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Concurrent radiation and chemotherapy treatment
  • Aerodigestive malignancy

Exclusion criteria

  • Other causes of vomiting (i.e.gastrointestinal obstruction...)

Treatment and study plan

Primary outcomes

  1. Assess incidence and patterns of nausea and vomiting in patients undergoing concurrent chemotherapy and radiation

    Time frame: week of treatment

Secondary outcomes

  1. Assess the impact of nausea and vomiting on the patients' daily functioning

    Time frame: week of treatment

  2. Study the incidence of mucositis and esophagitis

    Time frame: week of treatment

Sponsors and collaborators

Lead sponsor

Thomas Jefferson University

Other

Collaborators

  • Merck Sharp & Dohme LLC

Registry information

Official study title

A Prospective Study to Evaluate the Incidence and Patterns of Nausea and Vomiting in Patients Receiving Combined Chemotherapy and Radiation

Important dates

Study start
2004
Primary completion
2008
Study completion
2011
First posted
Jul 16, 2008
Registry last updated
Dec 5, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.