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Completed

NCT Number: NCT02378376

In Vivo Quantification of Short Chain Fatty Acids Production in the Human Colon

During this project the amount of SCFA produced in the colon after consumption of 2 different 13C-labelled wheat fiber fractions will be quantified.

Completed

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Key information

Conditions

Healthy

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Regular diet with 3 meals a day (minimal 5 times a week)
  • BMI between 18.5 and 27 kg/m2

Exclusion criteria

  • Calorie restricted diet or other special diet during the study or during the last month prior to the study
  • Antibiotics in the month prior to the study
  • Former surgeries on the gastrointestinal tract, with the exception of an appendectomy
  • use of the following types of medications with effects on the gastrointestinal tract during the last 2 weeks prior to the study (spasmolytica, anti-diarrhea, anti-constipation, probiotics)
  • Chronic disease of the gastrointestinal tract such as Crohn's disease, ulcerative colitis, irritable bowel syndrome, chronic constipation, chronic frequent diarrhea, clinically relevant lactose intolerance
  • Pregnancy, pregnancy desire or breastfeeding
  • Diabetes (type 1 and 2)
  • Blood donation in the past 3 months prior to the study
  • Abnormal hemoglobin (Hb) levels in blood, men must have a Hb level between 14.0 and 18.0 g / dL and women between 12.0 and 16.0 g / dL
  • Participation in studies in the past year in which radiation was used.

Treatment and study plan

Arabinoxylan oligosaccharides

Dietary Supplement

Dietary fiber enriched bran

Dietary Supplement

Primary outcomes

  1. Quantification of acetate, propionate and butyrate production in the colon after consumption of each wheat derived fiber fraction

    Time frame: 2 years

Sponsors and collaborators

Lead sponsor

KU Leuven

Other

Registry information

Official study title

In Vivo Quantification of Short Chain Fatty Acids Production in the Human Colon After Consumption of Different Cereal Fractions.

Important dates

Study start
2013
Primary completion
2014
Study completion
2015
First posted
Mar 4, 2015
Registry last updated
Mar 4, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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