In Vitro Maturation (IVM) for Polycystic Ovary Syndrome (PCOS)

Inclusion criteria

• 10 women between the ages of 18-34 inclusive at time of signing Informed Consent Form.
• A diagnosis of PCOS by their primary MD
• An Antral Follicular Count (AFC) of > 12 on one ovary on at least one occasion
• A day 3 FSH level of <8 IU/mL
• In good general health off of current medications which may confound response to study medications.
• Desire to seek pregnancy actively during the study period by IVF-ICSI.
• A normal uterine cavity must have been confirmed by either hydrosonogram or hysteroscopy within two years of entering the study.
• Male partner able to provide adequate semen sample by ejaculation (no TESE)

Exclusion criteria

• Current pregnancy
• Patients with uncorrected thyroid disease (defined as TSH < 0.2 mIU/ML or >5.5 mIU/mL). A normal level within the last year is adequate for entry.
• Patients with poorly controlled diabetes (HgB A1C over 8.0 ng/dL).
• Patients enrolled simultaneously into other investigative studies that require medications, proscribe the study medications, limit intercourse, or otherwise prevent compliance with the protocol.
• Patients with significant anemia (Hemoglobin < 10 mg/dL).
• Patients enrolled simultaneously into other investigative studies that would interfere with this research study.
• have any contraindications to using birth control pills (oral contraceptives) as determined by the attending physician (e.g. history of thromboembolism or estrogen-dependent malignancy, such as breast cancer, etc.) -