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Completed

NCT Number: NCT05512832

In-stent Restenosis and Pericoronary Fat Attenuation Index

This study aims to investigate the predictive value of fat attenuation index (FAI) and related radiomics characteristics of pericoronary fat in patients after percutaneous coronary intervention (PCI) for the occurrence of in-stent restenosis (ISR) during the follow-up period (9 to 24 months). The results of this study are expected to provide an early assessment of the inflammation around the coronary lesion segment in patients after PCI, and provide a basis for early targeted intensive drug therapy in clinical practice.

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Key information

Conditions

In-Stent Restenosis

Sex eligibility

All sexes

Study type

Observational

Primary location

Cardiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine

Shanghai, Shanghai Municipality, 200127, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with coronary heart disease who have undergone PCI;
  • Patients followed up coronary angiography 9 to 24 months after PCI;
  • Patients received chest CT examination during inpatient/outpatient follow-up;

Exclusion criteria

  • Patients with diseases of the immune system;
  • Patients with history of tumor diseases;
  • Patients with chronic/acute infectious diseases;
  • Image quality is not sufficient for analysis;

Treatment and study plan

Primary outcomes

  1. Fat attenuation index (FAI)

    Time frame: 2022.8.15-2023.8.14

    The pericoronary FAI was defined as the mean CT attenuation of the pericoronary adipose tissue (-190 to -30 HU). Peri-stent FAI was measured around the stent segment of all 3 major epicardial coronary vessels.

Sponsors and collaborators

Lead sponsor

RenJi Hospital

Other

Registry information

Official study title

Construction and Evaluation of Clinical Prediction Model of In-stent Restenosis After Percutaneous Coronary Intervention by Pericoronary Fat Attenuation Index and Radiomics Characteristics

Important dates

Study start
2020
Primary completion
2022
Study completion
2022
First posted
Aug 23, 2022
Registry last updated
Aug 23, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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