In-situ Cytokines Expression in the CNS in Amyotrophic Lateral Sclerosis (ALS)

The investigators aim at exploring the differential/topographical in-situ expression of cytokines in the central nervous system (CNS) of patients who died with amyotrophic lateral sclerosis (ALS), using archived histopathology slides and residual paraffin blocks from autopsied cases. Previous studies from the investigators and other groups showed that inflammatory cytokines are implicated in several neurological affections, particularly neurodegenerative conditions. However, in-situ cytokine expression has never been studied so far in ALS. The investigators wanted to see if these neuro-mediators are involved in the neuromolecular chain/cascade underlying ALS.

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Key information

Conditions

Amyotrophic Lateral Sclerosis Central Nervous System Diseases Metabolic Diseases Motor Neuron Disease Nervous System Diseases Neurodegenerative Diseases Neuromuscular Diseases Nutritional and Metabolic Diseases Proteostasis Deficiencies Spinal Cord Diseases TDP-43 Proteinopathies

Sex eligibility

All sexes

Study type

Observational

Primary location

CHU Brugmann

Brussels, 1020, Belgium

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

patients who died with amyotrophic lateral sclerosis, having been autopsied.

Exclusion criteria

Treatment and study plan

in-situ cytokine expression

Other

Primary outcomes

in situ cytokine detection: interleukin 18

Time frame: retrospective study performed on archived paraffin blocks, autopsies performed between 2000 and 2005

IHC detection on histopathology sections of paraffin embedded brain tissue.
in situ cytokine detection: interleukin 1

Time frame: retrospective study performed on archived paraffin blocks, autopsies performed between 2000 and 2005

IHC detection on histopathology sections of paraffin embedded brain tissue.
in situ cytokine detection: interleukin 6

Time frame: retrospective study performed on archived paraffin blocks, autopsies performed between 2000 and 2005

IHC detection on histopathology sections of paraffin embedded brain tissue.
in situ cytokine detection:TNF-a

Time frame: retrospective study performed on archived paraffin blocks, autopsies performed between 2000 and 2005

IHC detection on histopathology sections of paraffin embedded brain tissue.

Sponsors and collaborators

Lead sponsor

Brugmann University Hospital

Other

Registry information

Official study title

In-situ Cytokines Expression in the CNS in Amyotrophic Lateral Sclerosis

Important dates

Study start: 2012
Primary completion: 2015
Study completion: 2015
First posted: Oct 21, 2015
Registry last updated: Oct 21, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed