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NCT Number: NCT06132451

In-Hospital Detection of Elevated Blood Pressure

The goal of this clinical trial is to analyse the prevalence of new or uncontrolled arterial hypertension (AHT) after hospital discharge of medical in-patients with elevated blood pressure (BP) values during hospitalisation.

The main questions it aims to answer are:

* Do elevated BP values during hospitalisation correspond to new or uncontrolled AHT after hospital discharge? * Is it safe to postpone adaption of antihypertensive treatment until after proper evaluation of AHT after hospital discharge?

Participants will either be treated according to their physicians' decision or antihypertensive treatment adaptions will be postponed until after hospital discharge.

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Key information

Conditions

Hypertension Blood Pressure, High Cardiovascular Diseases Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University Hospital Basel

Basel, 4031, Switzerland

Location status: Recruiting

Location contact

Annina Vischer, M.D.

CONTACT

[email protected]

+41612652525

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient hospitalized on the internal medicine ward for non-cardiovascular causes, i.e. patients hospitalized for conditions, which are not acutely worsened by uncontrolled AHT
  • Asymptomatic elevated BP values (defined as 140-180 mmHg systolic and/or 90-110 mmHg diastolic) on at least 2 occasions
  • Ability to understand study procedures and to provide written informed consent

Exclusion criteria

  • Hospitalization for any conditions which can be worsened by uncontrolled AHT:
  • Cerebrovascular events
  • Acute coronary syndrome
  • Acute or decompensated heart failure
  • Any condition preventing ABPM
  • Pregnant or lactating women
  • Failure to provide informed consent

Treatment and study plan

Postponement of antihypertensive treatment

Other

Hypertensive blood pressure values in medical in-patients will not be treated during hospitalisation until confirmed by ABPM 4 weeks after hospital discharge

Primary outcomes

  1. Prevalence of persisting new or uncontrolled arterial hypertension

    Time frame: 4 weeks after hospital discharge

    Elevated blood pressure values in ambulatory blood pressure monitoring

  2. Prevalence of a combined hypertensive complication endpoint

    Time frame: Until 4 weeks after hospital discharge

    Consisting of intracerebral bleeding, ischemic stroke, myocardial infarction, cardiovascular death or cardiovascular re-hospitalization

  3. Prevalence of a combined hypotensive complication endpoint

    Time frame: Until 4 weeks after hospital discharge

    Consisting of falls, acute kidney injury, electrolyte disturbances, re-hospitalizations due to hypotension, or BP values on ABPM below the lower treatment limit

Secondary outcomes

  1. Clinic blood pressure measurement in mmHg

    Time frame: At baseline

    Documented in the patient documentation

  2. Research blood pressure measurement in mmHg

    Time frame: At baseline

    Standardized blood pressure measurement taken by research staff

  3. Prevalence of previously unknown arterial hypertension

    Time frame: At baseline

    No previously documented diagnosis of arterial hypertension and no antihypertensive treatment

  4. Prevalence of female gender

    Time frame: At baseline

    As reported by participant

  5. Prevalence of re-hospitalization for any cause

    Time frame: Until 4 weeks after hospital discharge

    According to hospital documentation and patient interrogation

Study contacts

Contact information is provided by the study sponsor or research team.

Annina Vischer, M.D.

CONTACT

[email protected]

+41612652525

Sponsors and collaborators

Lead sponsor

Annina Vischer

Other

Registry information

Official study title

In-Hospital Detection of Elevated Blood Pressure (INDEBP): Prevalence of New or Uncontrolled Hypertension and Safety of Postponement of Antihypertensive Treatment Adaption in Medical In-patients

Acronym: INDEBP

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Nov 15, 2023
Registry last updated
Sep 19, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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