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Completed

NCT Number: NCT00744601

Impulsivity, Neural Deficits and Cocaine Addiction

The purpose of this study is to assess neurocognitive and associated neural regions/circuitry disruptions relevant to impulsive relapse in cocaine-addicted subjects, and the relationship of the cognitive and neural mechanisms of impulsivity/decision-making to relapse style.

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Key information

Conditions

Cocaine Dependence Behavior Chemically-Induced Disorders Cocaine-Related Disorders Disease Attributes Impulsive Behavior Mental Disorders Pathologic Processes Pathological Conditions, Signs and Symptoms Recurrence Substance-Related Disorders

Age range

21 year–55 year

Sex eligibility

All sexes

Study type

Observational

Primary location

UT Southwestern Medical Center at Dallas, Divison on Addictions

Dallas, Texas, 75390-8564, United States

About this study

This study is designed to explore putative differences in impulsive behaviors and decision making in cocaine-addicted and healthy control subjects using functional magnetic resonance imaging (fMRI), single photon emission tomography (SPECT), and neurocognitive tasks. We predict that cocaine-addicted subjects will demonstrate neurocognitive and neural alterations in measures of impulsivity and decision-making when compared to healthy controls. That is, cocaine-addicted subjects will show both decreased activation and decreased resting measures of regional cerebral blood flow (rCBF) of the brain structures associated with impulsivity and decision-making. Furthermore, neurocognitive and neural deficits associated with impulsivity and decision-making will be associated with each other and with measures indicative of an impulsive relapse and altered decision making.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Cocaine-dependence (patient population) or no cocaine-dependence (control population).

Exclusion criteria

  • Other medical or psychiatric disorders that may effect neural functioning.
  • Medications that may effect neural functioning.

Treatment and study plan

Primary outcomes

  1. Determine if the brain regions involved in inhibition and decision-making are altered in cocaine-addicted subjects compared to healthy controls.

    Time frame: 2 weeks

  2. In cocaine-addicted subjects, determine if neural deficits during disinhibition or decision-making are related to relapse following treatment.

    Time frame: 6 months

Secondary outcomes

  1. Assess the predictive validity of self-report measures of impulsive relapse.

    Time frame: 6 months

Sponsors and collaborators

Lead sponsor

University of Texas Southwestern Medical Center

Other

Collaborators

  • Dallas VA Medical Center
  • National Institute on Drug Abuse (NIDA)

Registry information

Official study title

Impulsivity, Neural Deficits, and Relapse in Cocaine Addiction

Important dates

Study start
2007
Primary completion
2012
Study completion
2012
First posted
Sep 1, 2008
Registry last updated
Jan 3, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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