Impulsivity, Brain Function, and Substance Abuse Treatment in Cocaine Dependent Individuals

Cocaine dependence is a major public health problem; an effective primary treatment for cocaine dependent individuals has yet to be found. The purpose of this trial is to evaluate aspects of treatment response in cocaine dependent individuals.

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Key information

Conditions

Cocaine Abuse Chemically-Induced Disorders Cocaine-Related Disorders Mental Disorders Substance-Related Disorders

Age range

18 year–55 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Texas Health Science Center

Houston, Texas, 77030, United States

About this study

Cocaine is a strong central nervous system stimulant that is widely abused throughout the United States. Due to its widespread use, it is important to develop an effective treatment for cocaine dependence. The purpose of this study is to determine how impulsivity and prefrontal cortical function are related to treatment response in cocaine dependent individuals.

Participants in this study will complete four separate experiments, each with a different aim and testing panel [cognitive function tests with and without functional magnetic resonance imaging (fMRI)]. The first experiment will examine memory, attention, cognitive function, and impulsivity; the aim is to determine the relationship between impulsivity and cognitive function in cocaine dependent individuals receiving treatment. The second experiment will examine the relationship between impulsivity and the prefrontal cortical structure and function. Participants will complete an fMRI during the second experiment. The third experiment will consist of cognitive function tests and will examine the prefrontal cortex in relation to treatment response, based on four different treatments: 1) L-dopamine, 2) naltrexone, 3) modafinil, and 4) placebo. The fourth experiment will examine the effect of cocaine dependence treatment on prefrontal cortex, focusing on participants receiving modafinil.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Meets DSM-IV criteria for cocaine dependence
Met inclusion criteria for other cocaine dependence studies within the center grant

Exclusion criteria

Current or history of DSM-IV Axis I disorders, other than substance abuse or dependence
Lifetime diagnosis of alcohol dependence
Serious non-psychiatric medical illness requiring ongoing medical treatment or one that affects the central nervous system
Positive urine drug screen test for drugs of abuse other than cocaine at the time of study entry
AIDS-defining illness
Intelligence Quotient (IQ) below 70
Pregnant
Uses a pacemaker, metal or electromechanical implants, or metallic foreign bodies

Treatment and study plan

Primary outcomes

fMRI brain activation

Time frame: baseline

Baseline predictor of treatment response

Sponsors and collaborators

Lead sponsor

The University of Texas Health Science Center, Houston

Other

Collaborators

National Institute on Drug Abuse (NIDA)
University of Texas

Registry information

Official study title

Impulsivity, Brain Function and Substance Abuse Treatment

Important dates

Study start: 2005
Primary completion: 2013
Study completion: 2013
First posted: Sep 22, 2005
Registry last updated: May 9, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed