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NCT Number: NCT07380295

Improving Workforce Participation and Well-Being in Individuals With Multiple Sclerosis - A Feasability Study

Multiple sclerosis (MS) is a chronic neurodegenerative disease and a leading cause of reduced workforce participation due to neurological illness in Western countries. Over the past 30 years, new treatments have reduced symptom burden, allowing patients to stay in the workforce longer. However, fatigue and cognitive impairments remain major barriers to work capacity. This project aims to preliminary examine the impact of cognitive function on work ability, and assess the role of neuropsychologists in multidisciplinary rehabilitation teams. It consists of a feasibility study evaluating the integration of neuropsychological interventions into teambased work-oriented rehabilitation. The specific research questions are:

1. How can neuropsychological interventions be integrated into team-based work-oriented rehabilitation? 2. How do these interventions relate to work ability and well-being in individuals with MS? The investigators plan to collect data on 20 consecutively patients with MS before, 6 months after and 2 years after a neuropsychological testing and intervention. The patients are being followed on measures related to well-being and work ability. Data from the neuropsychological assessment, other rehabilitation interventions as well as data related to treatment and progress of MS are also collected.

Our findings aim to enhance work-oriented rehabilitation and provide a deeper understanding of how to support individuals with MS in maintaining employment and overall well-being

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Key information

Conditions

Multiple Sclerosis Autoimmune Diseases Autoimmune Diseases of the Nervous System Demyelinating Autoimmune Diseases, CNS Demyelinating Diseases Immune System Diseases Nervous System Diseases

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Multiple sclerosis Age between 18-65 Refered to neuropsychological assessment at the Neurology departement at Gävle Hospital -

Exclusion criteria

Other diagnosis hindering work participation more than MS

-

Treatment and study plan

Primary outcomes

  1. Work participation

    Time frame: From baseline to 2-year follow-up

    Percentage of full-time work. 100 % full-time work and 0% is not working at all.

  2. Hospital anxiety and depression scale

    Time frame: From baseline to 2-year follow-up

    Self-assessment of anxiety and depression. Consists of two scales measuring the probability of having anxiety and depression respectively. Min score 0, max 21 for each scale. Higher scores indicate higher probability of anxiety/depression.

  3. WHO-5 Well-Being Index

    Time frame: From baseline to 2-year follow-up

    Overall rating of well-being. The WHO-5 score range is a raw score of 0-25, which is then multiplied by 4 to get a percentage score of 0-100. Higher score indicates higher well-being.

  4. Brief index of job satisfaction

    Time frame: From baseline to 2-year follow-up

    The Brief Index of Affective Job Satisfaction (BIAJS) has a score range of 1 to 5 for each of its four items, based on a 5-point Likert scale where 1 is "strongly disagree" and 5 is "strongly agree". The total BIAJS score is the sum of these four items, resulting in a possible range from 4 to 20, with higher scores indicating greater affective job satisfaction.

Secondary outcomes

  1. Quantative work demands

    Time frame: From baseline to 2-year follow-up

    Questions from the subscale "Quantitative demands" of the Copenhagen Psychosocial Questionnaire (COPSOQ-III) related to the demands of work. The COPSOQ-III uses Likert-like scales, and its items are coded with values of 0, 25, 50, 75, and 100 to achieve a 0-100 scale. Higher scores indicate more demands.

  2. Can-Work-S

    Time frame: From baseline to 2-year follow-up

    Three questions from a questionnaire developed to measure work-life balance after cancer. Each item ranges from 1 to 5 with higher scores indicating worse work-life balance.

Study contacts

Contact information is provided by the study sponsor or research team.

Natascha Ekdahl

CONTACT

[email protected]

+4626278023

Sponsors and collaborators

Lead sponsor

Region Gävleborg

Other

Collaborators

  • University of Gavle

Registry information

Official study title

Improving Workforce Participation and Well-Being in Individuals With Multiple Sclerosis- A Feasability Study

Important dates

Study start
2025
Primary completion
2028
Study completion
2028
First posted
Feb 2, 2026
Registry last updated
Feb 2, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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