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Active, Not Recruiting

NCT Number: NCT07395466

Improving Weight Loss in Healthy Adults With Overweight and Obesity: An Artificial Intelligence-assisted Dietary Prediction and Prevention System With Continuous Glucose Monitoring

This study aims to examine the effectiveness of a novel dietary lapse prediction and prevention self-regulation app called the eating behaviour trigger-response inhibition program (eTRIP), and the addition of continuous glucose monitoring (CGM), on healthy eating and weight loss in people with overweight and obesity.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Overweight , Obesity Body Weight Nutrition Disorders Nutritional and Metabolic Diseases Obesity Overnutrition Overweight Overweight and/or Obesity Overweight or Obese Adults Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

21 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

National University of Singapore

Singapore, 117597

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • are 21-65 years old
  • have BMI ≥23 kg/m2
  • can comprehend the English language
  • uses a smartphone that can download apps
  • are willing to perform continuous glucose monitoring (CGM) using the Dexcom continuous glucose monitoring system
  • willing to travel to the National University of Singapore (NUS)
  • able to provide informed consent

Exclusion criteria

  • are using/intend to use other apps for weight loss;
  • are pregnant or lactating (as it would affect weight change and caloric needs)
  • are diagnosed severe mental disorders (e.g. major depressive disorder and schizophrenia)
  • are on prescribed meal replacements or pharmacotherapy
  • have serious medical conditions
  • are scheduled for any kind of surgery within the next 6 months

Treatment and study plan

eTRIP

Behavioral

Intervention group 1 involves using the eating behaviour trigger-response inhibition program(eTRIP) smartphone application for 10 weeks, where participants will need to take pictures of their food items as part of their food logging and may also engage with app-based activities to build self-regulatory skills in sticking to their weight loss plans. Additionally, participants will also apply a continuous glucose monitoring (CGM) sensor on their arm and taught how to scan the CGM sensor so that they can monitor their glucose levels for the first 10 days.

FatSecret

Other

Intervention group 2 involves using the FatSecret smartphone application for participants to monitor their calorie intake, without any continuous glucose monitoring.

Primary outcomes

  1. Height

    Time frame: At weeks 0, 10 and 24.

    Taken using a wall mounted measuring tape.

  2. Weight

    Time frame: At weeks 0, 10 and 24.

    Taken using InBody 120

  3. Waist Circumference

    Time frame: At weeks 0, 10 and 24.

    Taken using a measuring tape.

  4. BMI

    Time frame: At weeks 0, 10 and 24.

    Taken using InBody 120

  5. Self regulation of Eating Behaviour Questionnaire (SREBQ)

    Time frame: At weeks 0, 10 and 24.

    The Self-Regulation of Eating Behaviour Questionnaire (SREBQ) is a validated self-administered instrument used to assess individuals' self-regulation in relation to eating behavior. It evaluates the extent to which individuals monitor, control, and regulate their eating behaviors in everyday contexts. Higher scores indicate greater self-regulation of eating behavior.

Secondary outcomes

  1. Patient Health Questionnaire-2 (PHQ-2)

    Time frame: At weeks 0, 10 and 24.

    The Patient Health Questionnaire - 2 item (PHQ-2) is a validated self-administered screening questionnaire used to assess the frequency of depressive symptoms over the past two weeks. Higher scores indicate greater depressive symptom severity.

  2. Euro Quality of life 5 Dimensions-5 Levels (EQ-5D-5L)

    Time frame: At weeks 0, 10 and 24.

    The EuroQol 5 Dimensions - 5 Levels (EQ-5D-5L) is a standardized self-administered instrument used to assess health-related quality of life. It measures five dimensions: mobility, self-care, usual activities, pain/discomfort, and anxiety/depression, each with five response levels.

  3. Generalized Anxiety Disorder 2-item (GAD-2)

    Time frame: At weeks 0, 10 and 24.

    The Generalized Anxiety Disorder - 2 item (GAD-2) is a validated self-administered screening questionnaire used to assess the frequency of core anxiety symptoms over the past two weeks. Higher scores indicate greater anxiety symptom severity.

  4. Percentage Body Fat

    Time frame: At weeks 0, 10 and 24.

    Taken using InBody 120.

  5. Body Fat Mass

    Time frame: At weeks 0, 10 and 24.

    Taken using InBody 120.

  6. Three Factor Eating Questionnaire (TFEQ)

    Time frame: At weeks 0, 10 and 24.

    The Three-Factor Eating Questionnaire (TFEQ) is a validated self-administered instrument used to assess eating-related behaviors. It measures three domains: cognitive restraint of eating, uncontrolled eating, and emotional eating. Higher scores indicate greater levels of the respective eating behavior.

  7. International Physical Activity Questionnaire Short-Form (IPAQ-SF)

    Time frame: At weeks 0, 10 and 24.

    The International Physical Activity Questionnaire - Short Form (IPAQ-SF) is a validated self-administered questionnaire used to assess self-reported physical activity levels. It captures the frequency and duration of walking, moderate-intensity activity, and vigorous-intensity activity performed over the past 7 days.

  8. Self-Report Behavioural Automaticity Index (SRBAI)

    Time frame: At weeks 0, 10 and 24.

    The Self-Report Behavioural Automaticity Index (SRBAI) is a validated self-administered questionnaire used to assess the automaticity of behavior. It evaluates the extent to which a behavior is performed automatically, with little conscious thought or deliberation. Higher scores indicate greater behavioral automaticity.

  9. Consideration of Future Consequences Scale (CFCS-6)

    Time frame: At weeks 0, 10 and 24.

    The Consideration of Future Consequences Scale - 6 item (CFCS-6) is a validated self-administered questionnaire used to assess the extent to which individuals consider the potential future outcomes of their current behaviors. It evaluates the degree to which individuals weigh immediate versus future consequences when making decisions. Higher scores indicate greater consideration of future consequences.

  10. Skeletal Muscle Mass

    Time frame: At weeks 0,10 and 24.

    Taken using InBody 120.

  11. Visceral Fat Level

    Time frame: At weeks 0, 10 and 24.

    Taken using InBody 120.

  12. Big Five Inventory - 44 item (BFI-44)

    Time frame: At weeks 0, 10 and 24.

    The Big Five Inventory - 44 item (BFI-44) is a validated self-administered questionnaire used to assess personality traits across five domains: openness, conscientiousness, extraversion, agreeableness, and neuroticism. Higher scores indicate greater expression of the respective personality traits.

Sponsors and collaborators

Lead sponsor

National University Health System, Singapore

Other

Registry information

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Feb 9, 2026
Registry last updated
Feb 9, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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