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NCT Number: NCT05756985

Improving Understanding of Glioblastoma Through Preservation of Biologically Active Brain Tissue

To collect and preserve glioblastoma tissue during standard of care tumor resection surgery and blood for future molecular and genetic testing. Tissue for research will be collected from three different regions within the same tumor to study how these regions differ in their structure, DNA, and RNA and also to compare the data obtained from this testing to imaging data found in the medical record. The goal of this study is to help us better understand what the glioblastoma tumor tissue looks like and how it functions. This understanding can lead to new therapies for the treatment of glioblastoma in the future.

Recruiting

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Key information

Conditions

Glioblastoma Astrocytoma Glioblastoma Multiforme Glioma Gliosarcoma Neoplasms Neoplasms by Histologic Type Neoplasms, Germ Cell and Embryonal Neoplasms, Glandular and Epithelial Neoplasms, Nerve Tissue Neoplasms, Neuroepithelial Neuroectodermal Tumors

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Have the appearance of high-grade glioma on magnetic resonance (MR) imaging if allowed to consent and will undergo the procedure if the frozen is consistent with glioblastoma or gliosarcoma OR Patients with a history of histologically confirmed diagnosis of World Health Organization Grade glioblastoma or gliosarcoma that are undergoing repeat resection of a recurrent tumor as identified on preoperative MR imaging
  • Aged ≥ 18 years old
  • Contrast-enhancing tumor volume of at least 10 cc on the preoperative, volumetric MRI within 1 month prior to surgery
  • Provision of signed and dated informed consent form by participant or legally authorized representative (LAR), if applicable

Exclusion criteria

  • Has a history or current evidence of any medical condition, therapy, or laboratory abnormality that might confound the results of the study or is not in the best interest of the participant, in the opinion of the treating investigator.

Treatment and study plan

Specimen Collection

Procedure

Collect and preserve glioblastoma tissue for exploratory analyses to generate hypotheses for future studies.

Primary outcomes

  1. Number of glioblastoma (GBM) samples for analysis

    Time frame: 2 years

    Total number of GBM samples collected and preserved for analysis

Study contacts

Contact information is provided by the study sponsor or research team.

Manmeet S Ahluwalia, M.D.

CONTACT

[email protected]

(786) 596-2000

Michael McDermott, M.D.

CONTACT

[email protected]

(786) 596-2000

Sponsors and collaborators

Lead sponsor

Baptist Health South Florida

Other

Collaborators

  • Miami Cancer Institute
  • Nico Corporation

Registry information

Official study title

Improving Understanding of Glioblastoma Through Preservation of Biologically Active Brain Tissue (PRESERVE GBM)

Important dates

Study start
2024
Primary completion
2027
Study completion
2029
First posted
Mar 7, 2023
Registry last updated
Feb 4, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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