Improving Treatment for Depression in General Practice Using a Step-by-Step Care Plan.

Inclusion criteria

• The participant must be referred to the study with a diagnosis of unipolar depressive disorder, as judge by the GP.
• Severity of the depressive episode corresponding to moderate depression, as judged by the GP.
• Clinical uncertainty regarding which of the treatments, medication or psychotherapy, would be the better choice in the case concerned.
• Age criteria: Participants must be at least 18 years old and no more than 65 years old at the time of randomisation.
• The participant must be a patient in general practice.
• Participants must be able to participate in virtual meetings (e.g. by phone or computer) and have e-Boks.
• The participant must be willing to receive psychotherapy by a psychologist and/or medication.
• Must have signed the document of informed consent.

Exclusion criteria

• Misuse of substances that might influence the study, as judged by the investigator.
• Difficulty in understanding the Danish language, as judged by the investigator.
• A diagnosis of dementia.
• Medical conditions that might interfere with the study outcome or safety, judged so by the investigator.
• Pregnancy.
• High risk of non-adherence at the investigator's discretion.
• Suicidality: according to C-SSRS with a positive response to question 4 or 5 within the last three months or upon investigator's discretion.
• No current medical or psychotherapy treatment initiated within the last 4 weeks prior to screening.