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NCT Number: NCT07618117

Improving Sleep Health and Circadian Timing to Support Cardiometabolic Health in Adolescents

Many teenagers get too little and late timed sleep. High body weight and diabetes are increasing in teenagers as well. This study plans to learn more about whether improving sleep habits can help improve how the body regulates blood sugar and energy use in teenagers who have higher body weight. To answer this question, the investigators plan to enroll teenagers who get <7 hours of sleep on school nights and measure changes in blood sugars and energy use after two weeks of typical sleep (sleeping on their normal school schedule) and two weeks of a sleep intervention that includes spending longer time in bed at night, melatonin, and morning light.

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Key information

Conditions

Overweight Adolescents Glucose Metabolism Disorders Hyperinsulinism Insulin Resistance Insulin Sensitivity Metabolic Diseases Nutritional and Metabolic Diseases Sleep

Age range

14 year–19 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • High school students between 14-19 years
  • Overweight/obesity (BMI >85% for age and sex)
  • Have habitually insufficient sleep, defined as ≤ 7 hours per night on school days
  • Habitually inactive (≤ 3 h of physical activity reported per week)
  • Tanner stage 4 or 5, based on breast development for girls and testicular size for boys.

Exclusion criteria

  • Reported diagnosis of sleep disorder (e.g., insomnia, obstructive sleep apnea)
  • Medical comorbidities that impact sleep or insulin sensitivity (e.g., diabetes [based on history or screening HbA1c])
  • Regular use of medications affecting sleep or insulin sensitivity (e.g., stimulants, sleep aids, systemic steroids, insulin sensitizers, GLP-1 agonists)
  • IQ<70 or severe mental illness that may impact sleep or study participation (e.g., schizophrenia), eating disorder, or active suicidal ideation
  • Schedules that would preclude participants from adhering to the sleep schedules (e.g., night-shift employment)

Treatment and study plan

Circadian/Sleep (C/S)

Behavioral

1h additional time in bed, melatonin 2h before bedtime, and 30 minutes bright light after waking

Primary outcomes

  1. Insulin sensitivity

    Time frame: Assessed at 2 weeks following each condition

    Matsuda Index will be calculated from a mixed meal tolerance test (MMTT); higher values indicate better insulin sensitivity.

Secondary outcomes

  1. Total daily energy expenditure (TDEE)

    Time frame: Assessed for two weeks during each condition

    Assessed with doubly labeled water. Higher values indicate greater energy expenditure

  2. Average daily caloric intake (kcal/day)

    Time frame: Measured for 3 days during each condition

    Calculated from photographic diet diaries. Higher kcal indicates greater caloric intake.

Study contacts

Contact information is provided by the study sponsor or research team.

Angel Arias, BS

CONTACT

[email protected]

720-777-3491

Stacey L Simon, PhD

CONTACT

[email protected]

720-777-5681

Sponsors and collaborators

Lead sponsor

University of Colorado, Denver

Other

Collaborators

  • National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Registry information

Official study title

Mitigating Cardiometabolic Risk by Improving Sleep Health and Circadian Timing in Adolescents With Overweight/Obesity

Acronym: REST

Important dates

Study start
2026
Primary completion
2030
Study completion
2030
First posted
Jun 1, 2026
Registry last updated
Jun 1, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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