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NCT Number: NCT06790186

Improving Real-world Function for Persons with Schizophrenia: a Single-case Experimental Design

Existing treatment for individuals with psychosis primarily targets positive symptoms but has only modest effects on cognition and negative symptoms. Cognitive strategy training shows promising effects in reducing negative symptoms and increasing activity initiation in individuals with schizophrenia.

This project aims to investigate the effect of the Perceive, Recall, Plan and Perform (PRPP) intervention in promoting effective use of cognitive strategies for adults with schizophrenia in performing their daily activities. Twenty-seven individuals with schizophrenia will be recruited from Sykehuset Innlandet (Innlandet Hospital Trust) and assessed using PRPP prior to an eight-session PRPP intervention. Re-assessment will be conducted after the intervention, as well as at 3 and 6 months, to evaluate the long-term effects of the intervention. A single-case design will be used to investigate the intervention's effects. The primary outcome measure will be the PRPP assessment, and the secondary outcome measure will be the Goal Attainment Scale (GAS). Generalization measures will be used to evaluate whether there are relevant changes beyond the primary and secondary goals.

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Key information

Age range

18 year–59 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • DSM-5 diagnosis of schizophrenia, understand and speak Norwegian, live in their own community context, but are patients in Sykehuset Innlandet ( Innlandet Hospital Trust), either as outpatients or on discharge from inpatient care, a subjective experience of functional impairment and/or cognitive difficulties identified in an initial interview, and a stable state without any major medication change for at least two months before inclusion

Exclusion criteria

  • Major physical disability, a current substance abuse problem, and cognitive deficits of organic origin or mental retardation

Treatment and study plan

Perceive, Recall, Plan and Perform intervention Interventions:

Behavioral

The PRPP is a standardized system which determines the impact of information processing on performance of everyday activities. It is a method for assessment of performance mastery, and efficient use of cognitive strategies, as well as a model of intervention to train mastery and cognitive strategy use, in everyday activities. The PRPP assess task performance mastery, as well as cognitive strategy application

Primary outcomes

  1. PRPP assessment

    Time frame: Assesments just after the intervention, as well as at 3 and 6 months

    Effective use of cognitive strategies in performing their daily activities

Secondary outcomes

  1. Goal Attainment Scale

    Time frame: Assesments just after the intervention, as well as at 3 and 6 months

  2. Health of the Nation Outcome Scale

    Time frame: Assesments just after the intervention, as well as at 3 and 6 months

  3. Social Functioning Scale

    Time frame: Assesments just after the intervention, as well as at 3 and 6 months

  4. Questionnaire about the Process of Recovery

    Time frame: Assesments just after the intervention, as well as at 3 and 6 months

Study contacts

Contact information is provided by the study sponsor or research team.

Elisabeth Haug, PhD

CONTACT

[email protected]

0047 95781487

Pia Marie Reinfjord Johnsen, PhD candidate

CONTACT

[email protected]

0047 95761673

Sponsors and collaborators

Lead sponsor

Sykehuset Innlandet HF

Other

Collaborators

  • Norwegian University of Science and Technology

Registry information

Official study title

Improving Real-world Function for Persons with Schizophrenia (ImproFunc): a Single-case Experimental Design

Acronym: ImproFunc

Important dates

Study start
2025
Primary completion
2028
Study completion
2031
First posted
Jan 23, 2025
Registry last updated
Jan 23, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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