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OpenTrials
Completed

NCT Number: NCT00178932

Improving Outcome in Schizophrenia Through Identification of Genetic Risk Factors

The goals of this study are to replicate previous findings of genetic predictors of response to clozapine and other antipsychotic drugs.

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Key information

Conditions

Schizophrenia Bipolar Disorder Bipolar and Related Disorders Depressive Disorder Depressive Disorder, Major Major Depression Mental Disorders Mood Disorders Psychotic Disorders Schizoaffective Disorder Schizophrenia Spectrum and Other Psychotic Disorders

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Psychiatric Hospital at Vanderbilt

Nashville, Tennessee, 37212, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients with the diagnoses of schizophrenia or schizoaffective disorder, and bipolar disorder or major depression with psychotic features, or volunteers with no history of a psychotic disorder.

Exclusion criteria

Patients with DSM-IV diagnoses other than schizophrenia or schizoaffective disorder, and bipolar disorder or major depression with psychotic features.

Treatment and study plan

genetic analysis

Procedure

genetic assay of blood sample drawn with patient's consent

genetic assay

Procedure

genetic assay of blood sample drawn with patient's consent

Primary outcomes

  1. We plan to compare the polymorphisms across schizophrenic patients and adults who do not have a diagnosed major mental illness. .

    Time frame: single visit

Secondary outcomes

  1. We will also evaluate relationships between the polymorphism and past and current mental health among the non-diagnosed sample

    Time frame: single visit

Sponsors and collaborators

Lead sponsor

Northwestern University

Other

Registry information

Important dates

Study start
1998
Primary completion
2024
Study completion
2024
First posted
Sep 15, 2005
Registry last updated
Mar 18, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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