Improving Neuroprotective Strategy for Ischemic Stroke With Sufficient Recanalization After Thrombectomy by Edaravone Dexborneol

Inclusion criteria

• 18 to 80 years of age;
• Patients who presented with acute ischemic stroke and a large vessel occlusion in the anterior circulation and met the criteria of mechanical thrombectomy;
• Sufficient recanalization within 9 hours of stroke onset;
• Sufficient recanalization （TICI 2b-3）;
• Acute ischemic stroke with neurological baseline deficit equivalent to the National Institute of Health Stroke Scale (NIHSS) ≥ 6 before recanalization treatment;
• First ever stroke or mRS≤1 after previous disease
• The availability of informed consent.

Exclusion criteria

• Acute ischemic stroke patients with insufficient recanalization（TICI < 2a）
• Hemorrhagic transformation (PH2) indicated by NCCT performed after the operation immediately;
• Hemorrhagic stroke: cerebral hemorrhage, subarachnoid hemorrhage;
• Coagulation disorders, systematic hemorrhagic tendency, thrombocytopenia （ <100000/mm3）;
• Severe hepatic or renal dysfunction, increase in ALT or AST (more than 2 times of upper limit of normal value), increase in serum creatinine (more than 1.5 times of upper limit of normal value) or requiring dialysis;
• Severe hypertension (systolic blood pressure over 200mmHg or diastolic blood pressure over 110 mmHg);
• Patients with malignant tumor or under antineoplastic therapy with estimated lifetime less than 3 months;
• Pregnancy, plan to get pregnant or during lactation;
• Patients with contraindication or allergic to any ingredient of drugs in our study;
• Unsuitable for this clinical studies assessed by researcher.