Improving Metabolism With HDL Cholesterol

High levels of good cholesterol (HDL) in our blood decreases our chance of having a heart attack. This relates in part to the role good cholesterol plays in reducing build up of fat in the arteries. However, good cholesterol has many other protective effects. We have recently identified three enzymes (proteins) activated by HDL in cells lining the blood vessels, which may be responsible for some of HDL's protective actions.

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Key information

Conditions

Heart Disease Cardiovascular Diseases Diabetes Diabetes Mellitus Endocrine System Diseases Glucose Metabolism Disorders Heart Diseases Metabolic Diseases Nutritional and Metabolic Diseases

Age range

18 year–65 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Alfred Hospital

Melbourne, Victoria, 3004, Australia

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Aged 18 - 65 years
Free of overt coronary disease
Body mass index <35 kg.m-2
Fasting plasma glucose > 7 mmol/L-1
No major illness

Exclusion criteria

Unable to give informed consent
Smokers
Abnormal LFT, U&E, FBE or creatinine

Treatment and study plan

rHDL

Drug

Primary outcomes

Metabolic parameters

Sponsors and collaborators

Lead sponsor

Bayside Health

Other Gov

Collaborators

Baker Heart Research Institute

Registry information

Official study title

A Novel Mechanism Mediating Anti-atherosclerotic and Metabolic Actions of HDL Cholesterol

Important dates

Study start: 2006
Primary completion: 2008
Study completion: 2008
First posted: Nov 2, 2006
Registry last updated: May 10, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed