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OpenTrials
Completed

NCT Number: NCT04969341

Improving Lung Cancer Screening Adherence by Overcoming Barriers for Vulnerable Populations

This study investigates multi-level barriers to lung cancer screening uptake and adherence to lung cancer screening. Identifying cost- and convenience-related barriers to lung cancer screening may help researchers develop targeted strategies to facilitate screening adherence specifically among vulnerable populations.

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Key information

Conditions

Lung Carcinoma Lung Diseases Lung Neoplasms Neoplasms Neoplasms by Site Respiratory Tract Diseases Respiratory Tract Neoplasms Thoracic Neoplasms

Sex eligibility

All sexes

Study type

Observational

Primary location

Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, 19107, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All patients referred to the Jefferson LCSP and eligible for lung cancer screening by our standard criteria (United States Preventive Services Task Force, Center for Medicaid and Medicare Services, and/or National Comprehensive Cancer Network group II guidelines) will be eligible for inclusion in the study
  • Additionally, individuals must provide a signed and dated informed consent form to participate in the survey portion of this study

Exclusion criteria

  • Non-English-speaking individuals
  • Individuals who lack consent capacity

Treatment and study plan

Survey Administration

Other

Complete survey

Electronic Health Record Review

Other

Review of medical records

Primary outcomes

  1. Associations between health insurance availability and financial burdens as factors in lung cancer screening adherence

    Time frame: Up to study completion; 15 months

    Individual-level insurance status will be analyzed for association with lung cancer screening adherence. Descriptive analyses of neighborhood factors will be conducted to characterize residential computed tomography (CT)s. Multilevel logistic regression models examining the relationship between screening adherence and each neighborhood factor (i.e., one per model for each CT) and will be adjusted for important individual-level covariates, such as patient age, sex, and smoking status. To address the dependence of the neighborhood factors on race in predicting screening adherence, the modeling results will be focused on interaction terms to examine interactions between race and neighborhood factors.

  2. Individual-level cost-related factors associated with screening adherence

    Time frame: Up to study completion; 15 months

    Will use generalized linear mixed effects logistic regression to model the longitudinal adherence to lung cancer screening as a function of cost-related variables, race, and their interactions. The model will be used to estimate odds ratios representing how adherence associated with financial variables depends on race at each follow-up CT scan.

  3. Convenience-related factors that impact lung cancer screening adherence

    Time frame: Up to study completion; 15 months

    Will assess convenience-related factors that may affect lung cancer screening uptake and adherence. Survey items will address technology and internet accessibility; preferred methods for patient communication; effectiveness of patient navigation; and identification of logistical barriers along each step of the screening workflow including referral, eligibility assessment, scheduling, shared decision-making (SDM) visit, low dose CT (LDCT), results review, and follow-up instructions.

Sponsors and collaborators

Lead sponsor

Thomas Jefferson University

Other

Collaborators

  • Prevent Cancer Foundation

Registry information

Official study title

Improving Lung Cancer Screening Barriers for Vulnerable Populations

Important dates

Study start
2021
Primary completion
2023
Study completion
2023
First posted
Jul 20, 2021
Registry last updated
May 20, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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