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NCT Number: NCT07415109

Improving LDL-C Levels Through Temporal Self-regulation Theory-based, Personality-tailored Health Messages

The study is meant to run parallel to the larger study, RESET. The goal of this study is to to evaluate the effectiveness of a once-off general and personality-tailored text message on GP consultation among RESET participants identified to have high LDL-C. The main question it aims to answer is:

Will participants exposed to personality tailored advice have a higher adherence to GP consultation compared to the participants in the control group?

Researchers will compare a personalized message to a general message (with no personalization according to patients personality type) and control group to see if the messages increase adherence.

Participants are required to complete two questionnaires: one before and one after they receive their RESET results.

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Key information

Conditions

Adherence Preventive Health Services

Age range

21 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

National University of Singapore

Singapore, 117599

Location status: Recruiting

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • New participants of RESET who have given consent to be contacted for future studies
  • ≥21 years old

Exclusion criteria

  • are not able to read, write or communicate in English

Treatment and study plan

General Message

Behavioral

The intervention will consist of messages and infographics embedded in participants' return of results (ROR) emails within the RESET study. Each participant will receive the ROR alongside the intervention once, at the time their results are sent. No repeat messages will be delivered.

The general health message will include indications for lipid therapy, benefits of lipid-lowering medications, common side effects, risks of non-adherence, and an infographic on diet and lifestyle modification based on ACE lipid management guidance. The infographic will be included in the same ROR email.

Personalized Message

Behavioral

The intervention will consist of messages and infographics embedded in participants' return of results (ROR) emails within the RESET study. Each participant will receive the ROR alongside the intervention once, at the time their results are sent. No repeat messages will be delivered.

The message will include the personality-tailored message with the same core content as the general message, including indications for lipid therapy, benefits of lipid-lowering medications, common side effects, risks of non-adherence, and an infographic on diet and lifestyle modification based on ACE lipid management guidance. An infographic will be included in the same ROR email. This message will contain an added component framed according to conscientiousness and neuroticism scores, as these traits are strong predictors of health behaviours. Scores will be derived from baseline BFI-44 results.

Primary outcomes

  1. Intention to adopt a healthier diet

    Time frame: From enrollment to 3 months after results have been returned.

    A 3-item, 7-point Likert scale assessing participants' intention to adopt a healthier diet. The minimum and maximum score one can attain on this measure is 3 and 21 respectively, with a higher score indicating higher intention to adopt a healthier diet.

  2. Intention to engage in Physical Activity

    Time frame: From enrollment to 3 months after results have been returned.

    A 3-item, 7-point Likert scale assessing participants' intention to engage in physical activity. The minimum and maximum score one can attain on this measure is 3 and 21 respectively, with a higher score indicating higher intention to engage in physical activity.

  3. Intention to visit a General Practitioner

    Time frame: 3 months after results have been returned.

    A 3-item, 7-point Likert scale assessing participants' intention to visit a general practitioner. The minimum and maximum score one can attain on this measure is 3 and 21 respectively, with a higher score indicating higher intention to visit a general practitioner.

Other outcomes

  1. Big Five Inventory - 44

    Time frame: From enrollment

    A 44-item, 5-point Likert scale questionnaire that assesses the "Big Five" personality traits of a participant: namely Openness, Conscientiousness, Extraversion, Agreeableness, and Neuroticism, each represented as sub-scales. Subscale scores are calculated by summing the relevant items. The minimum / maximum score for each sub-scale is as follows, with higher scores indicating higher representation of the respective personality trait.

    Openness: 10/50 Conscientiousness: 9/45 Extraversion: 8/40 Agreeableness: 9/45 Neuroticism: 8/40

Study contacts

Contact information is provided by the study sponsor or research team.

Jocelyn Chew

CONTACT

[email protected]

+6565168687

Sponsors and collaborators

Lead sponsor

National University Health System, Singapore

Other

Registry information

Official study title

Improving LDL-C Levels Through Temporal Self-regulation Theory-based, Personality-tailored Health Messages: A Three-Arm Randomized Controlled Trial

Important dates

Study start
2025
Primary completion
2028
Study completion
2028
First posted
Feb 17, 2026
Registry last updated
Apr 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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