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NCT Number: NCT07488156

Improving Health Literacy in Patients With Schizophrenia Spectrum Disorder

The Impact of Health Literacy on the Attitudes toward Pharmacological Treatment in Patients with Schizophrenia Spectrum Disorder

This interventional study is aimed at:

* assessing and improving the health literacy and * assessing the attitude towards treatment of patients with schizophrenia spectrum disorders while they are admitted to the inpatient psychiatric unit.

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Key information

Conditions

Schizophrenia Disorder Mental Disorders Psychosis Psychotic Disorders Schizoaffective Disorder Schizophrenia Schizophrenia Spectrum and Other Psychotic Disorders

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University Medical Center

New Orleans, Louisiana, 70112, United States

Location contact

Jaudé Petrie, MD

CONTACT

[email protected]

504-702-3000

Jaudé Petrie, MD

PRINCIPAL_INVESTIGATOR

About this study

The study will take place at University Medical Center in New Orleans, LA and will include 34 patients with a schizophrenia spectrum disorder diagnosis who are admitted to the psychiatric unit. Participants will take tests to assess their knowledge of SSD before and after receiving educational materials during their hospitalization. They will also receive questionnaires assessing their attitudes toward treatment before and after the educational interventions. After each patient is provided with educational material, they will be allowed to ask the healthcare provider questions pertaining to schizophrenia. Following discharge, patients will be followed for a total of 12 months, where they will be called to answer questions about medication adherence.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients admitted to the University Medical Center-New Orleans (UMCNO) inpatient behavioral health unit ages 18 and older with a new or previous diagnosis of schizophrenia spectrum disorder outside of substance use disorders
  • Patients must be proficient in English.
  • Patients must have a government issued social security number (required for reimbursement through the university).

Exclusion criteria

  • Patients at UMCNO that are ages 17 or younger
  • Patients with SSD and concomitant intellectual disability, as evidenced by prior documented history on chart review or patients suspected to have intellectual disability or impairment based on clinical interactions
  • Patients with concomitant substance use and documentation of psychosis being resolved after a period of washout and without the use of psychotropic medications
  • Patients unable to complete health literacy assessments, attitude towards treatment assessments, and IQ testing due to severity of symptoms during hospitalization
  • Patients that are not proficient in English
  • Patients that do not have a government issued social security number

Treatment and study plan

Educational sessions

Behavioral

Patients will be given an educational pamphlet with information about schizophrenia spectrum disorders, including prognosis and management options. Following this, they will be allowed to ask the doctor any questions they have pertaining to schizophrenia spectrum disorder. In the second educational session, patients will watch a video containing information about schizophrenia spectrum disorders. Following this, they will be allowed to ask the doctor any questions they have pertaining to this topic.

Primary outcomes

  1. Post-intervention KAST (Knowledge About Schizophrenia Test) scores

    Time frame: This will be collected on Day 5 of the study, after the participant has completed both educational sessions.

    This includes an 18-item multiple choice test, with only one correct answer for each item. Scores range from 0 to 100%. Higher scores indicate a higher level of knowledge.

  2. Post-intervention ATT (Attitudes Toward Treatment) scores

    Time frame: This will be collected on Day 5 of the study, after the participant has completed both educational sessions.

    This test includes a total of 20 questions, each ranging from 0 to 10 points. Total score ranges from 0 to 200 points. Higher scores indicate a more favorable attitude towards medications.

Secondary outcomes

  1. MARS (Medication Adherence Rating Scale) scores

    Time frame: This questionnaire will be given on a monthly basis in the follow up period, for a total of 12 months.

    This is a 10-item questionnaire with only yes and no answer choices. Participants will be given 0 points for answers that represent poor adherence and they will be given 10 points for answers that represent good adherence. Scores will range from 0 to 100 points, with higher scores indicating more adherence.

Sponsors and collaborators

Lead sponsor

Louisiana State University Health Sciences Center in New Orleans

Other

Collaborators

  • Janssen Pharmaceuticals

Registry information

Official study title

The Impact of Health Literacy on the Attitudes Toward Pharmacological Treatment in Patients With Schizophrenia Spectrum Disorder

Important dates

Study start
2026
Primary completion
2027
Study completion
2028
First posted
Mar 23, 2026
Registry last updated
Mar 23, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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