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OpenTrials
Completed

NCT Number: NCT00774098

Improving Glycogen Liver Content Will Improve Post-operative Liver Function in Patients Undergoing Major Liver Resections

We would like to study the effect of preserving liver glycogen storage by using intravenous dextrose infusion on postoperative liver function and complications after major liver resections.

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Key information

Conditions

Liver Function

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Royal Victoria Hospital

Montreal, Quebec, H3A1A1, Canada

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18 years or older
  • planned to undergo a major liver resection at McGill University Health Center (MUHC)

Exclusion criteria

  • patients known with chronic viral liver disease
  • uncontrolled or type one diabetes mellitus (DM)
  • patients on oral beta-blocker agents
  • patients with unresectable disease determined intra-operatively
  • patients unable to give consent for the study.

Treatment and study plan

dextrose 10% (D10W ®) infusion

Drug

Started at 8pm the day before surgery until the procedure begins

hyperinsulinemic normoglycemic clamp

Drug

Started as the procedure begins, decreased at the end of the procedure and continued until 16 hours postoperatively

high calorie diet 35 kcal/kg

Dietary Supplement

High Calorie meals start the day before the surgery and are given 5 hours apart. The last meal is given at 7 pm the day before surgery

Intravenous normal saline (NS 0.9)

Drug

Intravenous normal saline (NS 0.9) started just before induction, and titrated to hemodynamic parameters and urine output

Primary outcomes

  1. Postoperative liver function test

    Time frame: Postoperative

Secondary outcomes

  1. Liver and muscle glycogen, TG, and protein content at beginning and end of the procedure.

    Time frame: Begining + end of the procedure

  2. Incidence of complications

    Time frame: Postoperative

Sponsors and collaborators

Lead sponsor

McGill University Health Centre/Research Institute of the McGill University Health Centre

Other

Registry information

Important dates

Study start
2007
Primary completion
2009
Study completion
2009
First posted
Oct 17, 2008
Registry last updated
Apr 1, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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