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Completed

NCT Number: NCT02426008

Improving Embryogenesis by Adding Growth Factors to In Vitro Human Culture Media

The investigators suppose that adding growth factors that had been found in the female tubal fluid and uterus to In Vitro single step culture media for human embryos might improve the the embryogenesis In Vitro and the clinical outcome of the resulting off spring.

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Key information

Conditions

In Vitro Human Embryo Development

Age range

18 year–40 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Ibnsina IVF center

Sohag, Egypt

About this study

The IVF culture media design and upgrade underwent many ideas during the last 3 decades, we suppose that adding growth factors ( Insulin-like growth factor I, Insulin-like growth factor II, transforming growth factor-beta and epidermal growth factor ) as a promoting growth factors to Lifeglobal culture media might improve embryo development in vitro so we decide to design a trial to compare the embryogenesis by sibling Oocytes of the same patient between to arm of the same culture media and the same culture condition but with one arm with growth factors and the other is traditional one and closely monitor the outcome within the 2 arms and record the results.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • all patients

Exclusion criteria

  • over 40 years old

Treatment and study plan

Growth Factors and Cytokine adding to embryo culture media

Other

No intervention

Other

Nothing to Add

Primary outcomes

  1. Clinical Pregnancy rate ( % )

    Time frame: 3 months

Secondary outcomes

  1. ongoing Pregnancy rate ( % )

    Time frame: 6 months

  2. rates of blastocyst formation and quality

    Time frame: 6 days of culture

Sponsors and collaborators

Lead sponsor

Ibn Sina Hospital

Other Gov

Collaborators

  • Banon IVF Center Assiut, Egypt

Registry information

Official study title

Growth Factors Supplementation to Single-Step Culture Medium

Acronym: GFSSSCM

Important dates

Study start
2015
Primary completion
2016
Study completion
2016
First posted
Apr 24, 2015
Registry last updated
Oct 2, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.