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OpenTrials
Completed

NCT Number: NCT06172725

Improvements by a Protein-rich Plant-based Diet and Resistance Exercise Program for Active Ageing

High-protein intake and physical activity are important approaches to preserve muscle mass. Consuming high levels of high-quality proteins to preserve muscle mass is challenging with a plant-based diet. Healthy, older participants will follow a twelve-week high-protein vegetarian diet or high-protein omnivorous diet both in combination with a resistance training program. The change in protein intake and muscle mass will be assessed.

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Key information

Conditions

Protein Intake

Age range

55 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Amsterdam University of Applied Sciences

Amsterdam, North Holland, 1067 SM, Netherlands

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Aged 55 years or older
  • BMI 18.5-30 kg/m2
  • Living independently
  • Ability and willingness to comply with the protocol
  • Written an informed consent
  • Consent of the study physician

Exclusion criteria

  • Alcohol abuse (more than 14 glasses per week (women) or more than 21 glasses per week (men)) or drug abuse in the opinion of the study physician (CBS et al., 2017)
  • Inability to understand the Dutch language
  • Cognitive impairment (MMSE more than 25)
  • Diagnosed chronic disease that may interfere with protocol (e.g., cardiovascular, gastrointestinal, neurological, known renal diseases (eGFR more than 60 mL/min), and/or diabetes)
  • Underwent bariatric surgery
  • Current enrolment in an exercise program or other intervention study
  • Planned a holiday during the intervention period and is unable to attend training sessions for more than 1 week

Treatment and study plan

Resistance Exercise intervention

Other

All participants will follow a resistance exercise program (3/week), which is personally guided by trainers.

Primary outcomes

  1. Protein intake

    Time frame: Three months

    Protein intake

  2. Appendicular lean mass

    Time frame: Three months

    Appendicular lean mass (DXA)

Sponsors and collaborators

Lead sponsor

Amsterdam University of Applied Sciences

Other

Registry information

Acronym: IMPACT

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Dec 15, 2023
Registry last updated
Feb 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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