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Completed

NCT Number: NCT00465777

Improved Management and in-Hospital Mortality

The study intend to evaluate whether the use of standardised malaria case management protocol plus financial incentives added to the availability of free drugs reduce the case-fatality at the paediatric ward.

Completed

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Key information

Conditions

Mortality Infections Malaria Mosquito-Borne Diseases Parasitic Diseases Protozoan Infections Vector Borne Diseases

Age range

3 month–5 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Bandim Health Project

Bissau, Bissau Region, 1004, Guinea-Bissau

About this study

Mortality at the national paediatric ward in Guinea-Bissau is very high. During a civil war in 1998/1999 the hospital case fatality (CF) decreased by more than 40%, increasing again after the the war. This was attributed to the available free drugs from the humanitarian aid and food incentives to the personnel. Free emergency kits for treatment of severe malaria was introduced, however the CF did not decline. Therefore, the ward was split into two groups of rooms: intervention and control. All the staff of the ward was trained in the use of a standardised guideline for treatment of severe malaria and randomly assigned to one of the groups. All children hospitalised for malaria received the drug emergency kits. The only difference in the intervention group were the small financial incentives and supervision for strict adherence to the guidelines procedures.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Hospitalization due to malaria
  • Non per os

Exclusion criteria

  • Consent from parent/caretaker declined

Treatment and study plan

Guideline adherence and financial incentive

Behavioral

Primary outcomes

  1. In-hospital case-fatality

Secondary outcomes

  1. Cumulative post-discharge mortality on day 28 and length of hospitalisation

Sponsors and collaborators

Lead sponsor

Bandim Health Project

Other

Collaborators

  • Statens Serum Institut
  • World Health Organization

Registry information

Official study title

Reduced in-Hospital Mortality After Improved Management of Patients Hospitalised With Malaria. A Randomised Trial

Acronym: MTV

Important dates

Study start
2004
Study completion
2006
First posted
Apr 25, 2007
Registry last updated
Apr 25, 2007

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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