Improve the Treatment of Thoracic Esophageal Cancer

According to different location of the primary lesion，the subject can be allocated to two sub-groups:

The patient with upper or middle thoracic esophageal cancer may be assigned to two field(T)-total mediastinal lymphadenectomy group,which is control group in this study or three field lymphadenectomy-Abdominal + mediastinal + cervical lymphadenectomy group,which is study group in this study randomly.

After the operation,the patient whose primary lesion is completely(R0) resected will be assigned to adjuvant chemotherapy group or interview group randomly.

Inclusion criteria

• Age≤70 years old;
• Karnofsky Performance Status（KPS）≥80;
• Pathological diagnosis is squamous cell carcinoma of thoracic esophageal which is treated initially;
• Clinical stage is c T 1 ~ 3 N 0 ~ 1 according to the results of endoscopic ultrasonography，chest and abdomen CT and neck ultrasonic.
• The preoperative evaluation of organ function is tolerant of surgery and chemotherapy;
• The subject can understand and sign the informed consent form (ICF);
• The following laboratory tests, made in 4 weeks before first medication, confirmed that bone marrow, liver and kidney function in line with the requirements to participate in research; Hemoglobin（HGB）≥9.0g/L; absolute neutrophils count（ANC）≥1.5×109/L; platelet count（PLT）≥100×109/L; total bilirubin（TBIL）≤1.5N;aspartate aminotransferase (AST)≤2.5N;alanine aminotransferase(ALT)≤2.5N;prothrombin time(PT)≤1.5N, and activated partial thromboplastin time(APTT) is in normal range;endogenous creatinine clearance rate(CRE)≤1.5N.

Exclusion criteria

• Cervical esophageal cancer and Non-squamous cell carcinoma of thoracic esophageal cancer;
• Advanced Esophageal Cancer;
• Prior malignancy in 5 years recently;
• History of previous chest radiotherapy;
• History of cardio-cerebral vascular accident in 6 months lately;
• The subject can not understand and sign the informed consent form(ICF).