Implication of Left veNtricle Vortex Flow Guided aNticOagulation Therapy for preVenting Apical Thrombus Formation In Patients With Acute myOcardial infarctioN: Multicenter Prospective Randomized Clinical Trial; INNOVATION Study

Implication of left veNtricle vortex flow guided aNticOagulation therapy for preVenting Apical Thrombus formation In patients with acute myOcardial infarctioN: Multicenter Prospective Randomized Clinical Trial; INNOVATION study

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Key information

Conditions

Apical Thrombus Formation Acute Myocardial Infarction Cardiovascular Diseases Embolism and Thrombosis Thrombosis Vascular Diseases

Age range

30 year–90 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Severance cardiovascular hospital

Seoul, 120-752, South Korea

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patient is ≥ 30 years old
Acute anterior wall myocardial infarction showing akinetic or dyskinetic apical wall motion abnormalities on an initial transthoracic echocardiogram
Left ventricular ejection fraction less than 40%

Exclusion criteria

Prior history of myocardial infarction
Chronic medication with Coumadin
Contraindication of contrast echocardiography
Significant atrial or ventricular arrhythmia
Valvular heart disease more than moderate degree
Decompensated heart failure
Very poor echo window, which cannot evaluate the presence of apical thrombus

Treatment and study plan

Primary outcomes

Apical thrombus formation in echocardiography

Time frame: 30 days after initial echocardiography

Evaluate and compare the incidence of thrombus formation in high risk group (Vortex depth < 0.45) and low risk group (Vortex Depth ≥ 0.45)

Sponsors and collaborators

Lead sponsor

Yonsei University

Other

Registry information

Important dates

Study start: 2012
Primary completion: 2015
Study completion: 2015
First posted: Jun 5, 2013
Registry last updated: May 10, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed