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NCT Number: NCT07199920

Implementation of New Multimodal MRI Sequences by Fingerprint to Improve Ischemic Stroke Examination.

Currently, standard brain MRI takes 20 to 25 minutes, but in the case of ischemic stroke, every minute counts to limit the extension of the necrotic core, with the possibility of recanalizing the occluded artery (intravenous thrombolysis and/or mechanical thrombectomy).

The recent concept of MRI "Fingerprint" (Magnetic Resonance Fingerprinting, MRF) allows the production of a rapid single sequence and the extraction of numerous parameters.

Demonstrating the feasibility and interpretability of multimodal MRI images acquired in MRF would make it possible to consider implementing and, ultimately, replacing conventional sequences, with the aim of shortening acute stroke management times, increasing the number of sequences acquired within a short timeframe (by increasing informativeness), and thus improving patients' short and long-term vital and functional prognosis.

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Key information

Conditions

Stroke, Ischemic Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Ischemic Stroke Nervous System Diseases Stroke Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Chu Grenoble Alpes

Grenoble, 38043, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age > 18 years
  • Subacute ischemic stroke patients (< 15 days after onset)
  • Middle cerebral artery or anterior cerebral artery territory stroke
  • Modified Rankin Scale (mRS) = 0-4

Exclusion criteria

  • MRI contraindications

Treatment and study plan

Achieva 3.0T dStream Philips

Device

Classic and MRF sequences will be carried out on the clinical machine (Achieva 3.0T dStream Philips) of the IRMaGe platform (CHUGA, Université Grenoble Alpes, Inserm, CNRS).

Primary outcomes

  1. Success rate and interpretability of images acquired in MRF

    Time frame: From enrollment to the end of the MRI exam

    Assessment of the success rate and interpretability (subjective evaluation with Likert scales of very satisfactory, satisfactory, insufficient, or unacceptable)

Secondary outcomes

  1. Characterize and extract the physical parameters of the signal acquired with MRF.

    Time frame: From enrollment to the end of the MRI exam

    Comparison of MRF imaging metrics: signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR), using mean values per ROI (region of interest).

    Segmentation and comparison of lesions, with calculation of the Dice similarity coefficient and/or SSIM (Structural SIMilarity).

    Visualization and description of artifacts encountered during acquisition (e.g., motion).

    Quantification of delays:

    Acquisition time: retrieval of raw data directly from MRI consoles. Reconstruction time: measurement of computation times. Extraction of information on cerebral microvas

Study contacts

Contact information is provided by the study sponsor or research team.

Zaza Putkaradze, Dr

CONTACT

[email protected]

0476767842

Sponsors and collaborators

Lead sponsor

University Hospital, Grenoble

Other

Collaborators

  • Grenoble Institut des Neurosciences

Registry information

Official study title

Implementation of New Multimodal MRI Sequences by Fingerprint to Improve Ischemic Stroke Examination, a Pilot Study and Proof of Concept

Acronym: INDEX

Important dates

Study start
2025
Primary completion
2026
Study completion
2027
First posted
Sep 30, 2025
Registry last updated
Sep 30, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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