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Completed

NCT Number: NCT05090475

Implementation of Academic Detailing Interventions on Prescribing of Antimicrobial Drugs in Primary Health Care

World increase in mortality from consequences of antimicrobial resistance (AMR) represents a significant public health problem. Irrational prescribing of antimicrobial drugs (AMD) in general population is one of the main causes of development AMR. This is also contributed by fact that up to 90% of total antimicrobial consumption in Europe is related to the general population. Problem of AMR has been recognized by World Health Organization and Council of European Union, which support the establishment of the antimicrobial stewardship team (A-team). A-team provides co-ordinated interventions that promote rational use of AMD. To date, no study has been carried out in which A-team from hospital environment goes to primary health care for the purpose of rationalization prescribing of AMD by primary health care practitioners. Project for implementation of hospital A-team in primary health care in Koprivnica-Križevci County was initiated using academic detailing method aimed at rationalization of the consumption of AMD.

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Key information

Conditions

Upper Respiratory Tract Infections Acute Respiratory Tract Infection Infections Respiratory Tract Diseases Respiratory Tract Infections Viral Infection Virus Diseases

Age range

25 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Koprivnica križevci county

Koprivnica, Koprivnica-Križevci County, 48000, Croatia

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All primary care physicians in Koprivnica Križevci County that agree to participate in the study

Exclusion criteria

  • Primary care physicians outside Koprivnica Križevci County

Treatment and study plan

academic detailing intervention

Behavioral

Academic detailing or educational outreach is a method based on scientific data with the help of educated A-team members in the form of direct (face-to-face) interactions, prescribing practices change and adherence improves according to the application of currently valid therapeutic guidelines

Primary outcomes

  1. Proportion of antimicrobials expressed as DDD per day for ATC group J01 associated with acute respiratory tract infections

    Time frame: 1 year

    Rationalization of consumption of antimicrobials for acute respiratory tract infections (for associated ICD diagnoses J01, J02, J03, J06, J20)

Secondary outcomes

  1. Change in Clostridiodes dificile infection for patients on antimicrobial therapy

    Time frame: 1 year

    Number of Clostridiodes dificile infection for patients on antimicrobial therapy. A case of Clostridioides difficile infection (CDI) is defined as diarrhoeal stools or toxic megacolon and a positive laboratory assay for C. difficile toxin A and/or B in stools or a toxin-producing C. difficile organism detected in stool via culture or other means e.g. a positive PCR result.

Sponsors and collaborators

Lead sponsor

General Hospital Koprivnica

Other

Collaborators

  • Interdisciplinary section for the control of antibiotic resistance (ISKRA)
  • Koprivnica Križevci County

Registry information

Official study title

Evaluating Hospital Educator-led Academic Detailing on Improving Antibiotic Prescribing in Primary Healthcare: a Feasibility Study

Important dates

Study start
2020
Primary completion
2020
Study completion
2022
First posted
Oct 22, 2021
Registry last updated
Jan 2, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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