Impedance Plethysmography Based Deep Vein Thrombosis Monitoring During Catheter-directed Thrombolysis

This study aims to collect IPG data set from healthy volunteers and DVT patients using ThrombUS+ prototype device developed during the project and commercial IPG device as a reference. The data will be used to develop ThrombUS+ IPG device, its signal processing and analysis algorithms and to train ML models.

Objectives of the study are to

• Collect IPG data for developing signal processing, data analysis and ML algorithms for DVT detection and assessment.
• Evaluate the performance of the developed methods to gold standard references including angiography, ultrasound imaging and venous occlusion plethysmography.
• Investigate whether multi-frequency IPG measurement improves the performance of DVT detection compared to single frequency measurement and determine the optimal measurement frequency.
• Investigate and compare different interventions to cause changes in venous blood volume for DVT detection, such as venous occlusion by thigh cuff, active respiration and muscle activation.

Secondary objectives are

• To investigate methods for simulating DVT and to compare the performance of these methods for DVT simulation.

Inclusion criteria

for Patients group:

• Age: 18 or older;
• DVT detected on other lower limb;
• Suitable for CDT treatment;
• Ability to give informed consent;
• Volunteering for the study.

Exclusion criteria

for Patients group:

• Age under 18 years;
• Inability to give informed consent;
• Denial;
• Too injured skin in the measurement area

Inclusion criteria

for Healthy volunteers group:

• Age: 18 or older;
• Ability to give informed consent;
• Volunteering for the study

Exclusion criteria

for Healthy volunteers group:

• Diagnosed DVT in lower limbs;
• Age under 18 years;
• Inability to give informed consent;
• Denial;
• Too injured skin in the measurement area.