Skip to main content
OpenTrials
Active, Not Recruiting

NCT Number: NCT04969081

Impact of Work Activity on SUD Outcomes

To date, there are no studies of the therapeutic effects of varied work-focused programs in Veterans undergoing outpatient substance use disorder (SUD) treatment. The investigators propose a randomized clinical trial to test the effects of work-focused programs on improving sobriety and other clinical outcomes in Veterans early in the course of recovery from SUD. Veterans will be randomized to either receive or not receive referral for work-focused therapeutic programs. Primary aim is to examine effects of work-focused programs on sobriety outcomes, namely sobriety and global functioning. Secondary aim is to examine effects of work-focused programs on psychiatric symptoms, self esteem/efficacy, and quality of life.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Notify Me

Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

VA Connecticut Healthcare System West Haven Campus, West Haven, CT

West Haven, Connecticut, 06516-2770, United States

About this study

The investigators propose a trial to test the effects of Incentive Therapy (IT) and Other Therapeutic and Supported Employment Services (Other TSES) on improving SUD outcomes in newly recovering Veterans in outpatient treatment. In line with eligibility criteria for different TSES programs, the investigators will employ a two branch study: One branch will be for Veterans who are not interested in pursuing competitive employment, and will be a two arm RCT with randomization (2:1) to referral for IT + treatment as usual (TAU; including usual SUD outpatient treatment) or TAU alone. The second branch will be for Veterans who express interest in competitive employment, and will be a two arm RCT with randomization (2:1) to referral for TSES competitive employment services + TAU or TAU alone. Total Intent to Treat sample will be 140 (n=70 per branch). Primary outcomes will be percent days abstinent during 3 month active phase and clinical global impression scale scores at 6 months. Secondary outcome will be psychiatric symptoms, self esteem/efficacy and quality of life.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Participants will be Veterans enrolled in VACHS substance use treatment, who at time of consenting into the study are within 30 days of detoxification or last substance use as per medical record.
  • Additional criteria will be as follows:
  • 18 years of age and older,
  • meeting DSM-V criteria for any current Substance Use Disorder (SUD) (e.g., opioids, cocaine, marijuana, amphetamine, or alcohol),
  • competent to give written informed consent and HIPAA authorization.

Exclusion criteria

  • involvement in a legal case that may lead to incarceration during study period;
  • developmental disability or medical illness that would prevent therapeutic work activity, as judged by PI or clinical staff providing this service;
  • plans to relocate outside geographic area that would make follow-up unlikely;
  • and/or lack of willingness to provide contact information of someone who can help us contact the participant in the event that we are unable to maintain contact directly.

Treatment and study plan

referral to work focused program

Behavioral

referral to Incentive Therapy or to Other Therapeutic and Supported Employment Services

Treatment as Usual

Other

usual treatment

Primary outcomes

  1. percent days abstinent

    Time frame: 3 months

    percent days abstinent during 3-month active phase

  2. Clinical Global Impression

    Time frame: 6 months

    Clinical Global Impression ratings conducted at 6 months from study entry.

Secondary outcomes

  1. change from baseline in BASIS-24

    Time frame: 3 months

    change in Behavior and Symptom Identification Scale, self-report

  2. change from baseline in Rosenberg self-esteem scale

    Time frame: 6 months

    change in self report of self-esteem

  3. change from baseline in New General Self-Efficacy Scale

    Time frame: 6 months

    change in self-report of self-efficacy

  4. change in WHOQOL BREF

    Time frame: 6 months

    change in self-report of quality of life

Sponsors and collaborators

Lead sponsor

VA Office of Research and Development

Fed

Registry information

Official study title

Augmenting Early Phase Substance Use Treatment With Therapeutic Work Activity to Improve Clinical Outcomes: a New Indication for an Old Intervention

Important dates

Study start
2022
Primary completion
2027
Study completion
2028
First posted
Jul 20, 2021
Registry last updated
Sep 17, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.