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NCT Number: NCT07467941

Impact of Visceral Adiposity on Postoperative Atrial Fibrillation After CABG

Obesity has become a major public health problem in both developed and developing countries, with a continuous increase particularly since the 1980s. Moreover, it is a well-established metabolic risk factor for diabetes mellitus, hypertension, and various types of cancer, as well as cardiovascular diseases such as heart failure and coronary artery disease. Body mass index (BMI) is calculated by dividing body weight in kilograms by the square of height in meters and is widely used as an indicator of obesity. However, BMI does not quantitatively reflect body fat distribution and fails to account for components such as skeletal muscle and bone mass. Therefore, interest in assessing body fat distribution has increased, and in recent years, studies evaluating the correlation between anthropometric, biochemical, and anatomical measurements and clinical outcomes have become more frequent. In particular, it is acknowledged that abdominal obesity cannot be accurately represented by BMI alone and is primarily associated with visceral adipose tissue (VAT). The aim of this study is to evaluate the association between preoperative visceral and subcutaneous adipose tissue measurements (VAT and SAT), assessed by ultrasonography in patients scheduled for open-heart surgery, and the development of postoperative atrial fibrillation.

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Key information

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Elective isolated coronary artery bypass graft surgery (on-pump)
  • Age ≥18 years, planned prospectively in 300 patients

Exclusion criteria

  • Patients requiring urgent or emergency surgery
  • Off-pump coronary artery bypass graft surgery
  • Surgeries other than isolated coronary artery bypass graft
  • Patients in whom abdominal ultrasound measurement cannot be performed (e.g., due to severe deformity, wounds, edema)
  • Active malignancy
  • eGFR <30 mL/min
  • Advanced-stage chronic obstructive pulmonary disease (COPD)
  • Preoperative atrial fibrillation or atrial flutter
  • Patients who do not provide written informed consent for the study

Treatment and study plan

Postoperative AF Group

Other

In patients undergoing coronary artery bypass graft surgery, ultrasound-guided measurements of visceral and subcutaneous adipose tissue will be performed preoperatively. The relationship between adipose tissue thickness and the development of postoperative atrial fibrillation will be evaluated by comparing patients who develop AF with those who do not.

Non-AF Group

Other

In patients undergoing coronary artery bypass graft surgery, ultrasound-guided measurements of visceral and subcutaneous adipose tissue will be performed preoperatively. The relationship between adipose tissue thickness and the development of postoperative atrial fibrillation will be evaluated by comparing patients who develop AF with those who do not.

Primary outcomes

  1. Effect of visceral adipose tissue thickness on postoperative atrial fibrillation

    Time frame: Within 7 days after coronary artery bypass graft surgery or until hospital discharge

    Preoperative ultrasound-guided measurement of visceral adipose tissue thickness will be performed. The association between visceral fat thickness and the development of postoperative atrial fibrillation will be evaluated.

Study contacts

Contact information is provided by the study sponsor or research team.

OZGE PEKSEN KIZILISIK

CONTACT

[email protected]

+905439406027

Sponsors and collaborators

Lead sponsor

Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital

Other Gov

Registry information

Official study title

Impact of Visceral Adiposity on Postoperative Atrial Fibrillation After Coronary Artery Bypass Grafting (CABG): A Prospective Observational Study

Important dates

Study start
2026
Primary completion
2026
Study completion
2027
First posted
Mar 12, 2026
Registry last updated
Mar 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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