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Completed

NCT Number: NCT06629961

Impact of Transepithelial Abutment Connection and Disconnection in Dental Implants

Over the past decade, implant research has focused on maintaining the health and stability of peri-implant tissues. A key factor is platform switching at the bone level, where a narrower abutment than the implant is used. This technique increases the implant's horizontal surface area for biological width establishment and reduces stress on the crestal bone.

Studies showed that repeated disconnection and reconnection of prosthetic components could compromise the mucosal barrier around implants, leading to an apical shift in the connective tissue junction and vertical tissue loss. This led to the "one abutment, one time" protocol, advocating the placement of the definitive abutment during initial implant surgery to avoid its removal during healing.

A recent meta-analysis indicated bone loss at the marginal level due to abutment connection and disconnection, despite different treatment protocols. Thus, a standardized abutment between the fixed prosthesis and the implant has been recommended to preserve marginal bone levels. This approach moves the biological width apically, protecting the bone from irritation and improving marginal bone isolation.

However, comparative evidence between direct implant-connected prostheses and trans-epithelial abutments is lacking. This study aims to evaluate the "one abutment, one time" protocol's effect on bone loss 12 months after prosthesis placement.

Secondary objectives include assessing patient satisfaction using Patient-Reported Outcome Measures (PROM) during prosthesis fabrication and placement, and obtaining information on the diversity and function of microorganisms on the implant using metagenomic techniques 12 months post-prosthesis placement.

Throughout the prosthesis fabrication and the first 12 months, various evaluations will be conducted in both abutment and Ti-base groups:

* **Bleeding:** Recorded during various prosthetic stages. * **Pain:** Assessed using a visual analog scale after each stage. * **Anesthesia:** Recorded if used at each stage. * **Radiographs:** Number taken to check the fit. * **Time:** Measured for each prosthetic phase. * **Repetitions:** Number of repeated procedures quantified. * **Metagenomic tests:** Samples collected following the Human Microbiome Project protocol to analyze microbial diversity and function.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Clínica Odontológica de la Universitat de Valencia, Fundación Lluis Alcanyis, Valencia, Spain

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Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy partially edentulous adult patients needing at least two implants for the placement of single or consecutive crowns in the posterior mandible or maxilla will be recruited.
  • These patients should exhibit a plaque index and gingival bleeding index of less than 25%, and have sufficient bone height and width for the placement of dental implants measuring 8 or 10 mm in length and 3.5 or 4 mm in diameter.
  • Additionally, they must have at least 2 mm of keratinized vestibular gingiva, stable occlusion, and a periodontium in good health

Exclusion criteria

  • Edentulous areas requiring bone grafts will be excluded.
  • Patients with medical conditions contraindicating implant surgery, such as severe bruxism or inadequate oral hygiene.
  • Pregnant or lactating women, patients undergoing bisphosphonate therapy, those receiving chemotherapy or radiotherapy in the head and neck area, non-compliant patients with incomplete data records, and those who do not attend regular follow-up appointments will also be excluded.

Treatment and study plan

abutment placement

Procedure

Placement of a subcrestal implant at more than 35 N and placement of a trans-epithelial abutment at 30 N

Ti-base placement

Procedure

Placement of a subcrestal implant at more than 35 N and placement of a Tibase placement at 30 N

Primary outcomes

  1. periimplant marginal bone loss

    Time frame: 12 months

    The peri-implant marginal bone level was measured using Image J software from the National Institutes of Health with an accuracy of 0.1 mm. A straight line was drawn at the implant platform level (representing zero height), and perpendicular lines were drawn from the mesial and distal sides of the platform to measure the distance to the bone level on each side

Sponsors and collaborators

Lead sponsor

University of Valencia

Other

Registry information

Official study title

Impact of Connection and Disconnection of the Transepithelial Abutment in Dental Implants

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Oct 8, 2024
Registry last updated
Jul 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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