Impact of Time Restricted Eating on Patients With Coronary Artery Disease (CAD) Undergoing Cardiac Rehabilitation

Inclusion criteria

• Age: 18-75 years
• Enrollment and planned participation in UC San Diego's 9-week Intensive Cardiac Rehabilitation Program
• Established diagnosis of coronary artery disease (concomitant systolic or diastolic HF is allowable)
• Own a smartphone (Apple iOS or Android OS)
• If patients are on cardiovascular medications (HMG CoA reductase inhibitors (statins), other lipid modifying drugs (including over the counter drugs such as red yeast rice and fish oil), anti-hypertensive, anti-diabetes drugs, no dose adjustments will be allowed during the study period.

Exclusion criteria

• Taking insulin within the last 6 months.
• Known inflammatory and/or rheumatologic disease.
• Active tobacco abuse or illicit drug use or history of treatment for alcohol abuse.
• Pregnant or breast-feeding women.
• Shift workers with variable (e.g. nocturnal) hours.
• Caregivers for dependents requiring frequent nocturnal care/sleep interruptions.
• Planned international travel during study period.
• Systolic HF alone.
• Heart transplant within the past 1 year.
• Presence of left ventricular assist device.
• Uncontrolled arrhythmia (i.e. rate-controlled atrial fibrillation/atrial flutter are not exclusion criteria).
• History of thyroid disease requiring dose titration of thyroid replacement medication(s) within the past 3 months (i.e. hypothyroidism on a stable dose of thyroid replacement therapy is not an exclusion).
• History of adrenal disease.
• History of malignancy undergoing active treatment, except non-melanoma skin cancer.
• History of type I diabetes with ongoing insulin dependence.
• History of eating disorders.
• History of cirrhosis.
• History of stage 4 or 5 chronic kidney disease or requiring dialysis.
• History of HIV/AIDS.
• Currently enrolled in a weight-loss or weight-management program. This does not include UC San Diego's Cardiac Rehabilitation Programs.
• On a special or prescribed diet for other reasons (e.g. Celiac disease).
• Currently taking any medication that is meant for, or has a known effect on, appetite.
• Any history of surgical intervention for weight management.
• Uncontrolled psychiatric disorder (including history of hospitalization for psychiatric illness).
• Baseline eating window <14 hours per day as documented on mCC app.
• Failure to use the smartphone app for documentation (defined as <2 meals/day for ≥3 days during baseline).