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OpenTrials
Completed

NCT Number: NCT02886650

Impact of Thermocoagulation During Invasive EEG Monitoring in Children With Focal Drug-resistant Epilepsies

When focal epilepsies become drug-resistant, it could be eligible for cortical surgical resection. Therefore, an invasive EEG monitoring with depth electrodes is often needed during presurgical evaluation. Some of these children can have access to thermocoagulation inside the ictal onset zone, at the end of the monitoring and before to remove the electrodes. These thermocoagulations can disorganize the epileptogenic network thanks to millimetric cortical lesions around the electrodes. The aim is to stop or at least, to reduce the seizure frequency for few weeks or months. This could be a benefit for the child, and also a confirmation of the ictal onset zone and guide the surgeon. This technique is currently used in adult population for years, but remains very rare in children.

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Key information

Age range

18 month–17 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Fondation Ophtalmologique Adolphe de Rothschild

Paris, 75019, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • age 18 month to 17 years old
  • focal drug-resistant epilepsy
  • small size lesion (1 or 2 gyri) or cryptogenic epilepsy
  • indication for EEG monitoring with depth electrodes during presurgical evaluation

Exclusion criteria

  • formal contraindication to surgery or anaesthesia
  • functional area or potentially large epileptic area
  • refusal to participate in the study
  • no health insurance coverage

Treatment and study plan

Thermocoagulation

Procedure

Thermocoagulation During pre-surgical Invasive EEG Monitoring

Primary outcomes

  1. Number of children with a decrease of at least 50% of the seizure frequency

    Time frame: one month after surgery

Sponsors and collaborators

Lead sponsor

Fondation Ophtalmologique Adolphe de Rothschild

Network

Registry information

Acronym: COAG

Important dates

Study start
2015
Primary completion
2023
Study completion
2024
First posted
Sep 1, 2016
Registry last updated
Apr 15, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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