Impact of the Procurement Technique on Outcomes After Liver Transplantation

Liver transplantation (LT) is the standard treatment for hepatocellular carcinoma (HCC) and end-stage liver disease, with excellent long-term outcomes despite the increasing use of extended criteria donors due to organ shortage. As traditional evaluation criteria have become insufficient, new indicators such as Arterial and Biliary Complication-Free Survival (ABCFS) have been developed to better assess post-transplant outcomes.

Primary objective: To assess, in a large-scale study, whether the procurement technique influences liver transplantation outcomes in terms of arterial and biliary complication-free survival.

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Key information

Conditions

Liver Transplantation Adenocarcinoma Carcinoma Carcinoma, Hepatocellular Digestive System Diseases Digestive System Neoplasms Liver Diseases Liver Neoplasms Neoplasms Neoplasms by Histologic Type Neoplasms by Site Neoplasms, Glandular and Epithelial

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients aged 18 years or older at the time of inclusion
Listed on the national waiting list of the Agence de la Biomédecine (ABM)
Undergoing a first liver transplantation in France
Receiving a whole liver graft
No prior or subsequent transplantation of another organ

Exclusion criteria

Pancreas procurement
Multiorgan transplantation
Split liver transplantation (shared grafts)
Retransplantation
Domino transplantation (no actual organ procurement in the conventional sense)
Patient refusal to allow the use of their data

Treatment and study plan

Primary outcomes

Arterial and Biliary Complication-Free Survival (ABCFS) at 3 years

Time frame: at 3 years post-transplantation

Secondary outcomes

Postoperative complications at 90 days

Time frame: at 90 days post-transplantation
Type of Biliary complications

Time frame: Up to 3 years post-transplantation
Type of Arterial complications

Time frame: Up to 3 years post-transplantation
Occurrence of vascular injuries observed following organ procurement

Time frame: Peri-procedural period (during procurement and immediately post-procurement)
Rehospitalization Rate Post-LT

Time frame: Up to 3 years post-transplantation

Number of rehospitalizations per patient occurring after the initial transplantation hospitalization.
Duration of Rehospitalizations Post-LT

Time frame: Up to 3 years post-transplantation

Length of stay for each rehospitalization occurring after the initial transplantation hospitalization.
Reasons for Rehospitalizations Post-LT

Time frame: Up to 3 years post-transplantation

Reason for each rehospitalization occurring after the initial transplantation hospitalization, categorized by diagnosis.

Study contacts

Contact information is provided by the study sponsor or research team.

Eric Savier, MD, PhD

CONTACT

[email protected]

+33 1 42 17 56 90

Jinmi BAEK

CONTACT

[email protected]

Sponsors and collaborators

Lead sponsor

Assistance Publique - Hôpitaux de Paris

Other

Registry information

Official study title

Impact of the Procurement Technique on Outcomes After Liver Transplantation: a French Multicenter Prospective Study

Acronym: PLVT_TH

Important dates

Study start: 2026
Primary completion: 2031
Study completion: 2031
First posted: May 13, 2026
Registry last updated: May 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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