Impact of Surgery for Deep Posterior Endometriosis on Ovarian Reserve (ENDORO)

Inclusion criteria

• Female, aged 18 to 39 years old;
• Suspected severe deep posterior pelvic endometriosis on reference pelvic MRI (ovarian kissing, obliteration of the pouch of Douglas) with concordant clinical examination, or confirmed severe deep posterior pelvic endometriosis during exploratory laparoscopy;
• Patient affiliated with or covered by a social security plan;
• Patient having been informed and having given her free, informed, and written consent

Exclusion criteria

• Presence of ovarian involvement defined by the presence of at least one endometrioma >5 mm;
• History of surgery for severe deep endometriosis;
• Severe preoperative premature ovarian insufficiency (defined by AMH <1ng/mL and antral follicle count <8);
• Concurrent use of GnRH agonist therapy at or within the preceding 3 months of enrollment;
• BMI >35 kg/m²;
• Menopausal status;
• Patient participating in another trial with an exclusion period that has not yet expired at the time of screening;
• Protected patient: adult under guardianship, curatorship, or other legal protection, deprived of liberty by judicial or administrative decision;
• Pregnant, breastfeeding, or postpartum woman.