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Completed

NCT Number: NCT03374436

Impact of Sprint Stair Climbing "Snacks" on Markers of Metabolism and Vascular Function

Prolonged sitting has been shown to impair metabolism and vascular function. The overall purpose of this study is to determine if breaking up prolonged (9 hours) of sitting with brief (~20 second) stair climbing exercise "snacks" can improve markers of metabolic control and vascular health in healthy young male participants and in males or females with overweight/obesity who are at risk of insulin resistance. An additional purpose is to determine if saliva insulin can be used as a valid indicator of blood insulin when measured throughout the day in sedentary and active conditions and when diets with different amounts of carbohydrates are consumed.

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Key information

Conditions

Physical Activity Behavior Diet Modification Motor Activity

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of British Columbia Okanagan

Kelowna, British Columbia, V1V 3G1, Canada

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Lean Group Inclusion Criteria:

Non-smoking

Lean Group Exclusion Criteria:

Diagnosed with diabetes or prediabetes (fasting blood sugar more than 6.0 mmol/l) or any other chronic condition that may impact glucose or insulin levels.

BMI is over 25 kg/m2 Take medications which may affect glucose and insulin levels Allergic to eggs. Smoker Competitive or serious endurance athlete.

Overweight/Obese Group Inclusion Criteria:

Elevated waist circumference (>102 cm for male and >88 cm for female)

Overweight/Obese Group Exclusion Criteria:

Diagnosed with diabetes (fasting blood sugar more than 7.0 mmol/l) Take medications which may affect glucose and insulin levels Allergic to eggs. Smoker Competitive or serious endurance athlete.

Treatment and study plan

High-Carbohydrate Sedentary

Behavioral

Three high-carbohydrate meals will be consumed (breakfast, lunch, and dinner) at ~3 hour intervals while participants remain in a seated position for the entire 9 hour intervention period.

High-Carbohydrate Active

Behavioral

Three high-carbohydrate meals will be consumed (breakfast, lunch, and dinner) at ~3 hour intervals while participants remain in a seated position for the entire 9 hour intervention period except that once every hour they will ascend three flights of stairs vigorously (stair climbing sprint "snack") for a total of 8 active breaks.

Low-carbohydrate Sedentary

Behavioral

Three low-carbohydrate meals will be consumed (breakfast, lunch, and dinner) at ~3 hour intervals while participants remain in a seated position for the entire 9 hour intervention period. This condition will provide a condition where the blood glucose and insulin responses are relatively low and stable throughout the day.

Primary outcomes

  1. Plasma insulin area under the curve

    Time frame: Measured across 9 hours of each intervention day

    The plasma insulin concentration measured by enzyme-linked immunosorbent assay area under the curve will be measured using the trapezoidal rule.

Secondary outcomes

  1. Saliva insulin area under the curve

    Time frame: Measured across 9 hours of each intervention day

    The saliva insulin concentration measured by enzyme-linked immunosorbent assay area under the curve will be measured using the trapezoidal rule.

  2. Plasma glucose area under the curve

    Time frame: Measured across 9 hours of each intervention day

    The plasma glucose concentration measured by hexokinase method area under the curve will be measured using the trapezoidal rule.

  3. Plasma triglyceride area under the curve

    Time frame: Measured across 9 hours of each intervention day

    The plasma triglyceride concentration measured by biochemical assay area under the curve will be measured using the trapezoidal rule.

  4. Plasma non-esterified fatty acids area under the curve

    Time frame: Measured across 9 hours of each intervention day

    The plasma non-esterified fatty acid concentration measured by biochemical assay area under the curve will be measured using the trapezoidal rule.

  5. Femoral artery flow-mediated dilation

    Time frame: Measured in the morning (time 0 hours) and afternoon (time 8.5 hours) each intervention day

    Flow-mediated dilation of femoral artery measured by vascular ultrasound

  6. Cerebrovascular function

    Time frame: Measured in the morning (time 0.5 hours) and afternoon (time 6 hours) each intervention day

    Cerebrovascular function measured by transcranial doppler ultrasound

  7. Cognitive function

    Time frame: Measured in the morning (time 0.5 hours) and afternoon (time 6 hours) each intervention day

    Cognitive function measured by Computerized Neurocognitive Assessment Software (CNS) Vital Signs test battery

Sponsors and collaborators

Lead sponsor

University of British Columbia

Other

Collaborators

  • CoreHealth Technologies Inc.
  • Mitacs

Registry information

Official study title

Salivary Insulin Profiles Throughout the Day in Healthy Humans

Important dates

Study start
2017
Primary completion
2019
Study completion
2019
First posted
Dec 15, 2017
Registry last updated
Sep 25, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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