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NCT Number: NCT06944600

Impact of Sleep Disorders and Digital Support on Older People's Health

The goal of this observational study is to learn about the effects of sleep disorders on health and ageing in older people over the age of 65.

The main question it aims to answer is: How do sleep disorders impact the motoric and cognitive ageing trajectories of older individuals? Participants will undergo a set of instrumental, laboratory and clinical diagnostic examinations to comprehensively assess the impact of sleep disorders on health.

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Key information

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥ 65 years;
  • MMSE score adjusted by age and education ≥ 25/30;
  • Absence of mobility-disability;
  • Absence of need for assistance with Basic Activities of Daily Living (according to the ICFSR International Clinical Practice Guidelines).

Exclusion criteria

  • Individuals with specific clinical conditions that make the intervention unsafe (I.e., severe diseases, unstable health status);
  • Individuals whose adherence to the protocol might be low due to clinical (E.g., cognitive impairment, dialysis) and non-clinical (E.g., plans to relocate out of the study area within the next 3 years) reasons;
  • Individuals unable or unwilling to provide informed consent;
  • Consumption of more than 14 alcoholic drinks per week [one alcoholic drink (equal to 14.0 grams of pure alcohol) corresponds to 36 cc of beer (5% alcohol content), 24 cc of malt liquor (7% alcohol content), 15 cc of wine (12% alcohol content), 4.5 cc of distilled spirit or liquor (40% alcohol content)];
  • Difficulty in communicating with the study staff due to speech, language, or (non-corrected) hearing and vision problems;
  • Severe arthritis (E.g., awaiting joint replacement) that would interfere with the ability to fully participate in the study;
  • Lung disease requiring regular use of supplemental oxygen;
  • Severe cardiovascular disease (including New York Heart Association [NYHA] class III or IV, clinically significant congestive heart failure and valvular disease, history of cardiac arrest, presence of an implantable defibrillator or pacemaker, uncontrolled angina);
  • Upper and/or lower extremity amputation;
  • Peripheral arterial disease Lériche-Fontaine 3 or 4;
  • Renal disease requiring dialysis;
  • Current enrolment in another study involving lifestyle, nutrition, or pharmaceutical interventions;
  • Further medical, psychiatric, or behavioural factors that in the judgment of the principal investigator may interfere with the study participation;
  • Further possible illnesses affecting the life expectancy and reducing it to less than 24 months, corresponding to the study's length;
  • Clinical judgment concerning safety or non-compliance, as well as the conditions for which the use of the Sleep Profiler is not recommended (sensitivity of skin or scalp and/or open wounds on the forehead or scalp, allergic reactions to extended exposure to synthetic fabrics (e.g., polyester, rayon), upper respiratory infection or congestion, head circumference less than 21 or greater than 25 inches, forehead vertical measurement (from top of eyebrows to hairline) less than or equal to 2 inches or horizontal measurement (from hairline to hairline) less than or equal to 6 inches).
  • SPPB score <3 at baseline.

Treatment and study plan

Primary outcomes

  1. Incidence of physical and functional worsening

    Time frame: 12 months

Secondary outcomes

  1. Prevalence and incidence of sarcopenia

    Time frame: 24 months

  2. Prevalence of mild cognitive impairment (MCI) and cognitive frailty

    Time frame: 24 months

  3. Incidence of mild cognitive impairment (MCI) and cognitive frailty

    Time frame: 24 months

  4. Incidence of dementia in cognitive frail older individuals

    Time frame: 24 months

  5. Prevalence and incidence of recognised pre-frailty conditions

    Time frame: 24 months

  6. Prevalence and incidence of malnutrition, polypharmacy and multimorbidity

    Time frame: 24 months

Study contacts

Contact information is provided by the study sponsor or research team.

Marcello G Maggio

CONTACT

[email protected]

+39 0521 703916

Sponsors and collaborators

Lead sponsor

University of Parma

Other

Registry information

Official study title

The Role of Sleep Disorders in the Motoric and Cognitive Trajectories of Older Physically Frail Sarcopenic and Healthy Active Subjects

Acronym: SOMNUS-DARE

Important dates

Study start
2025
Primary completion
2027
Study completion
2027
First posted
Apr 25, 2025
Registry last updated
Apr 25, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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