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NCT Number: NCT03964116

Impact of Sick Peer Relation on Adaptation to Disease and on Treatment of Cancer-suffering Adolescents & Young Adults

Adolescents and young adults (AYA) with cancer have to deal with a relatively segmented organization of care between pediatric and adult medicine structures in France. However, the third french Plan Cancer 2014-2019 helped in the recognition of the specificities of the AYA affected by cancer and allowed the creation of specific structures in some care units in France, whose primary goal is the preservation of the social link.

Indeed, peer relations contribute to access to quality social support, which is an important variable in patient adjustment with cancer. The adolescents that perceive higher social support report less psychological distress and exhibit higher adaptation scores.

It nevertheless happens that AYA experience negative social support, often from friends because of contact reduction during the disease. Patients can then elect to turn towards non-intimate relations such as support groups. The main risk when a AYA with cancer defines a sick peer as one bringing him quality social support is the installation of a sense of guilt, for example, when a young person is confronted with disease negative progress or with peer death. The more an adolescent identifies with the deceased, the more he is able to consider his own mortality.

AYA units are developing in France, creating a community of sick adolescents. These communities are precious for AYA and allow information and experience sharing, a feeling of reduced isolation and a greater emotional closeness with peers suffering from the same disease.

How is social support from peers and close friends perceived by these young people in AYA units and through the social networks? What can the consequences of the evolution of peer disease be on AYA? What is the impact of the mourning of sick peers on these young people? What are the predictors?

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Key information

Age range

15 year–27 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

INSTITUT CURIE - site Paris, Paris, Île-de-France Region, France

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About this study

Methodology: Multicentric, prospective, not randomized study.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adolescents or young adults from 15 to 27 years old (included) receiving cancer diagnose or recurrence announcement.
  • Patient information and free consent signature by the patient or his legal representative(s).

Exclusion criteria

  • Patient with any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol.
  • Inability to understand, talk or write in French.
  • Patient individually deprived of liberty or placed under the authority of a tutor.

Treatment and study plan

Questionnaires set all 3 months

Other

This longitudinal study based upon repeated and multicentric measurement will recruit AYA with cancer in care Units dedicated to them or not. Measures will be quantitative, and repeated every 3 months by questionnaires, as well as qualitative (social network questionnaire, psychological research interview) for teenagers declaring a negative event or a death event during treatments.

Those patients presenting a high depression score will be contacted by a research psychologist for semi-directed interview.

Other names: Psychological interviews

Primary outcomes

  1. Social support on patients psychological adjustment

    Time frame: 4 years

    Compare the social support received and its effects on psychological adjustment in AYA unit groups versus groups without AYA unit (socio-demographic questionnaire).

  2. Social support on patients psychological adjustment

    Time frame: 4 years

    Compare the social support received and its effects on psychological adjustment in AYA unit groups versus groups without AYA unit (BDI-II questionnaire).

  3. Social support on patients psychological adjustment

    Time frame: 4 years

    Compare the social support received and its effects on psychological adjustment in AYA unit groups versus groups without AYA unit (STAI-Y questionnaire).

  4. Psychological adjustment & quality

    Time frame: 4 years

    Compare psychological adjustment in the 2 groups and its quality according to important events (positive or negative) that affect sick peers (STAI-Y questionnaire).

  5. Psychological adjustment & quality

    Time frame: 4 years

    Compare psychological adjustment in the 2 groups and its quality according to important events (positive or negative) that affect sick peers (BDI-II questionnaire).

  6. Predictors of the grief quality

    Time frame: 4 years

    Define if there are predictors of the grief quality: personality? Attachment? Other life events? Depression? Nature of the link with dead peers? (RSQ questionnaire).

  7. Predictors of the grief quality

    Time frame: 4 years

    Define if there are predictors of the grief quality: personality? Attachment? Other life events? Depression? Nature of the link with dead peers? (SSQ6 questionnaire).

  8. Predictors of the grief quality

    Time frame: 4 years

    Define if there are predictors of the grief quality: personality? Attachment? Other life events? Depression? Nature of the link with dead peers? (BFI-Fr questionnaire).

  9. Grief phenomenon (real or virtual life)

    Time frame: 4 years

    Describe the grief phenomenon and observe if there are demonstrations of grief when the peer was never met in person (ITG questionnaire).

  10. Grief phenomenon (real or virtual life)

    Time frame: 4 years

    Describe the grief phenomenon and observe if there are demonstrations of grief when the peer was never met in person (SEC questionnaire).

Sponsors and collaborators

Lead sponsor

Institut Curie

Other

Collaborators

  • University of Paris 5 - Rene Descartes

Registry information

Official study title

Impact of Sick Peer Relation on the Adaptation to Disease and on Treatment of Cancer-suffering Adolescents and Young Adults (PEERS-AYA)

Acronym: PAIRS-AJA

Important dates

Study start
2018
Primary completion
2023
Study completion
2024
First posted
May 28, 2019
Registry last updated
Aug 11, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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