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NCT Number: NCT07388797

Impact of Serum Progesterone Levels on Embryo Transfer Day on Clinical Pregnancy

Hypotheses:

We hypothesize that serum progesterone levels on the day of embryo transfer in HRT-FET cycles are positively associated with clinical pregnancy rates.

Aims:

To evaluate the relationship between serum progesterone levels on embryo transfer day and clinical pregnancy outcomes in frozen-thawed embryo transfer cycles using hormone replacement therapy (HRT).

Primary outcome:

To compare the incidence of clinical pregnancy outcome in those infertility patients undergoing frozen embryo transfer with caterized Progesterone level on the day of embryo transfer

Secondary outcomes:

Biochemical pregnancy rate. Implantation rate. Early pregnancy loss rate. Ectopic pregnancy rate.

Recruiting

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Key information

Conditions

Reproductive Issues

Age range

18 year–42 year

Sex eligibility

Female

Study type

Observational

Primary location

The Chinese University of Hong Kong

Hong Kong, China

Location status: Recruiting

Location contact

Chung PW Pui Wah, Jacqueline

CONTACT

[email protected]

35051537

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients undergoing FET cycles
  • Infertility patients aged >18 years old and < 42 years old
  • BMI < 30 kg/m2
  • Transfer of at least one good-quality embryo.

Exclusion criteria

  • Severe endocrine disorders (e.g., thyroid dysfunction, premature ovarian failure).
  • Severe uterine factors without treatment (severe endometriosis, extensive or subendometrial fibroid, uterine adherent, endometrial polyps)

Treatment and study plan

Primary outcomes

  1. Clinical pregnancy rate (CPR)

    Time frame: 6 weeks of gestation and ultrasound scanning will be performed to confirm at least one gestational sac around 1 to 3 months after FET

    Rate of clinical pregnancy outcome in subjects undergoing FET

Secondary outcomes

  1. Biochemical pregnancy rate

    Time frame: Up to 12 weeks

    Rate of biochemical pregnancy outcome in subjects undergoing FET

  2. Implantation rate

    Time frame: Up to 12 weeks

    Rate of implantation in subjects undergoing FET

  3. Early pregnancy loss rate

    Time frame: Up to 12 weeks

    Rate of early pregnancy loss in subjects undergoing FET

  4. Ectopic pregnancy rate

    Time frame: Up to 12 weeks

    Rate of Ectopic pregnancy in subjects undergoing FET

Sponsors and collaborators

Lead sponsor

Chinese University of Hong Kong

Other

Registry information

Official study title

Impact of Serum Progesterone Levels on Embryo Transfer Day on Clinical Pregnancy in Frozen-thawed Embryo Transfer Cycles Using Hormone Replacement Therapy: a Prospective Observational Study

Important dates

Study start
2026
Primary completion
2028
Study completion
2028
First posted
Feb 5, 2026
Registry last updated
May 11, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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