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OpenTrials
Completed

NCT Number: NCT07499453

Impact of Sequential Double Embryo Transfer on Live Birth Rates: A Case-Control Study.

The main aim of this study is to evaluate the impact and identify potential indications for sequential double embryo transfer (SEQ-ET) in couples undergoing assisted reproductive technology (ART). The study will compare live birth rates (LBR) between patients receiving SEQ-ET and those receiving standard double embryo transfer (DET), while assessing safety outcomes and potential indications, including endometrial immune under-activation. Each SEQ-ET case will be matched with a DET control based on age, transfer attempt rank, and ART technique. We hypothesize that SEQ-ET may enhance implantation in couples with previous ART failures without increasing the risk of complications, potentially through localized maternal-endometrial immune communication initiated by the initially transferred cleavage-stage embryos.

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Key information

Conditions

Infertility Genital Diseases Urogenital Diseases

Age range

20 year–42 year

Sex eligibility

Female

Study type

Observational

Primary location

Hôpital Pierre Rouquès - Les Bluets.

Paris, 75012, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Infertile patients undergoing IVF with planned SEQ-ET or DET.
  • Age ≤ 42 years.

Exclusion criteria

  • Age aged 43 years.
  • Cycles in which only a single embryo was ultimately transferred and cycles in which no embryo transfer occurred.

Treatment and study plan

Primary outcomes

  1. Live birth rate

    Time frame: From first embryo transfer to delivery (up to approximately 9 months).

    LBR defined as delivery of a viable infant beyond 24 weeks of gestation, assessed after the first fresh or frozen blastocyst transfer.

Secondary outcomes

  1. Clinical Pregnancy Rate

    Time frame: 6-8 weeks after embryo transfer.

    Clinical pregnancy confirmed by ultrasound visualization of a gestational sac.

  2. Miscarriage Rate per Clinical Pregnancy

    Time frame: Up to 24 weeks of gestation.

    Pregnancy loss before 24 weeks of gestation among clinical pregnancies.

  3. Implantation Rate

    Time frame: 6-8 weeks after embryo transfer.

    Number of gestational sacs per number of embryos transferred.

  4. Multiple pregnancies

    Time frame: Up to 9 months

    Percentage of multiple pregnancies regardless of whether one or two day-2/3 are transferred before the day-5 embryo are transferred.

Sponsors and collaborators

Lead sponsor

Hopital Pierre Rouques - Les Bluets

Other

Registry information

Official study title

A CASE-CONTROL OBSERVATIONAL STUDY ON THE IMPACT OF A SEQUENTIAL DOUBLE EMBRYO TRANSFER POLICY ON LIVE BIRTH RATES IN COUPLES UNDERGOING ASSISTED REPRODUCTIVE TECHNOLOGY.

Acronym: SEQ-ET

Important dates

Study start
2014
Primary completion
2023
Study completion
2024
First posted
Mar 30, 2026
Registry last updated
Mar 30, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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