Impact of Renal Replacement Therapy on Coagulation Profile of Patients with Acute Renal Failure

Renal failure and high plasmatic level of urea have been associated with an increased risk of hemorrhage in surgical patients. There is only sparse data on the impact of renal replacement therapy on homeostatic parameters. The aim of this study is to describe potential changes in homeostatic parameters before and after renal replacement therapy.

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Key information

Conditions

Acute Renal Failure Acute Kidney Injury Cardiovascular Diseases Coagulation Disorder Embolism and Thrombosis Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Hematologic Diseases Hemic and Lymphatic Diseases Hemorrhage Hemorrhagic Disorders Hemostatic Disorders Kidney Diseases Male Urogenital Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Renal Insufficiency Thrombosis Urogenital Diseases Urologic Diseases Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

CHRU de Brest

Brest, 29609, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

critically ill patients
acute renal failure
renal replacement therapy
plasmatic urea > 20

Exclusion criteria

chronic renal failure
platelet count less than 80 Giga
V factor less than 70%

Treatment and study plan

Primary outcomes

visco elastometry

Time frame: Change in ROTEM parameters from baseline to after renal replacement therapy

ROTEM (Rotational Thromboelastometry)

Sponsors and collaborators

Lead sponsor

University Hospital, Brest

Other

Registry information

Official study title

Impact of Renal Replacement Therapy on Coagulation Profile in Patients with Acute Renal Failure

Acronym: HEMOSTIR

Important dates

Study start: 2018
Primary completion: 2021
Study completion: 2021
First posted: May 24, 2018
Registry last updated: Mar 24, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed