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Enrolling by Invitation

NCT Number: NCT07159256

Impact of Processing Speed on Motor, Balance, Gait, and Quality of Life in Stroke"

Stroke rehabilitation programs are traditionally designed based on the evaluation of motor and sensory impairments starting from the acute phase. Although studies in diseases such as multiple sclerosis and Parkinson's disease have shown that information processing speed may affect motor function and balance, no such study has been conducted in stroke patients.

This study aims to investigate the effect of information processing speed on motor function, balance, gait, and quality of life in patients with ischemic stroke.

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Key information

Conditions

Stroke Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Ischaemic Stroke Ischemic Stroke Nervous System Diseases Vascular Diseases

Age range

40 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Istanbul Aydın University

Istanbul, Küçükçekmece, 34295, Turkey (Türkiye)

About this study

A review of the literature reveals that in stroke patients, motor and sensory impairments are evaluated beginning in the acute phase, and rehabilitation programs are structured accordingly. While research has demonstrated that information processing speed can influence motor function and balance in other neurological conditions such as multiple sclerosis and Parkinson's disease, no similar studies exist for stroke populations.

The investigators hypothesize that early evaluation of motor, sensory, and cognitive deficits in patients with ischemic stroke, and incorporating these findings into rehabilitation programs, may positively impact prognosis.

This study will recruit patients admitted for treatment at the Physical Medicine and Rehabilitation Unit of Istanbul Aydın University VM Medical Park Florya Hospital. Inclusion criteria are: age ≥ 40 years, first-ever ischemic stroke, hemodynamic stability, literacy, and absence of pre-stroke psychiatric, neurological, visual, auditory, or orthopedic conditions that may affect mobilization. Additionally, patients must score full points in the vision and speech domains of the NIHSS after stroke.

Eligible participants' demographic and clinical data will be recorded. Information processing speed will be assessed using the Symbol Digit Modalities Test (SDMT). Motor function will be evaluated with the Fugl-Meyer Assessment (FMA), balance with the Berg Balance Scale (BBS) and the Sense4Motion Euleria Health device, gait with the Timed Up and Go Test (TUG), and quality of life with the Stroke-Specific Quality of Life Scale (SS-QOL).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 40 years or older
  • First-ever ischemic stroke
  • Hemodynamically stable
  • Able to read and write (literate)
  • No history of psychiatric, neurological, visual, auditory, or orthopedic conditions prior to stroke that could affect mobilization
  • After stroke, full scores in the vision and speech domains according to the NIH Stroke Scale (NIHSS)

Exclusion criteria

  • Recurrent stroke
  • Post-stroke visual or hearing impairment
  • Neglect
  • Aphasia
  • Conditions causing impaired consciousness such as dementia, confusion, or delirium
  • Presence of cardiovascular or orthopedic conditions after stroke that prevent mobilization
  • Age 75 years or older

Treatment and study plan

Primary outcomes

  1. Symbol Digit Modalities Test (SDMT) Score

    Time frame: At baseline (single assessment)

    The Symbol Digit Modalities Test (SDMT) will be used to assess information processing speed. The test requires participants to match symbols with corresponding numbers according to a reference key within 90 seconds. The total number of correct responses will be recorded, with higher scores indicating better processing speed.

Secondary outcomes

  1. Berg Balance Scale (BBS) Score

    Time frame: At baseline (single assessment)

    The Berg Balance Scale (BBS) will be used to evaluate functional balance. The test consists of 14 tasks, including sitting, standing, reaching, and turning activities, each scored on a 5-point scale from 0 (unable to perform) to 4 (independent performance). The total score ranges from 0 to 56, with higher scores indicating better balance.

  2. Fugl-Meyer Assessment (FMA) Score

    Time frame: At baseline (single assessment)

    The Fugl-Meyer Assessment (FMA) will be used to evaluate motor function in stroke patients. The scale assesses movement, coordination, and reflexes of the upper and lower extremities. Scores range from 0 to 100, with higher scores indicating better motor function and recovery.

  3. Stroke-Specific Quality of Life Scale (SS-QOL) Score

    Time frame: At baseline (single assessment)

    The Stroke-Specific Quality of Life Scale (SS-QOL) will be used to assess health-related quality of life. It consists of 49 items across 12 domains (e.g., mobility, mood, energy, self-care, social roles). Each item is scored on a 5-point Likert scale, with higher scores indicating better quality of life.

  4. Balance Assessment with Sense4Motion Euleria Health / Euleria Lab Device

    Time frame: At baseline (single assessment)

    The Sense4Motion Euleria Health (Euleria Lab) device will be used for objective balance assessment. This wearable inertial sensor system measures postural stability and body sway during standardized balance tasks. Quantitative parameters such as sway velocity, sway area, and stability index will be recorded. Lower sway values and higher stability indices indicate better balance performance.

  5. Timed Up and Go Test (TUG) with Euleria Health / Euleria Lab

    Time frame: At baseline (single assessment)

    The gait module of Euleria Health (Euleria Lab) device will be used to perform the Timed Up and Go (TUG) test. Participants will be asked to rise from a chair, walk three meters, turn, return, and sit down. The device's inertial sensors will record spatiotemporal gait parameters such as duration (seconds), number of steps, gait speed, and turning characteristics. Lower times and more stable gait parameters indicate better functional mobility.

Sponsors and collaborators

Lead sponsor

Istanbul Aydın University

Other

Registry information

Official study title

The Effect of Information Processing Speed on Motor Function, Balance, Gait, and Quality of Life in Patients With Ischemic Stroke

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Sep 8, 2025
Registry last updated
Sep 11, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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