Impact of Pre- and Post-operative Serum Metabolome Dynamics in Colorectal Resection Outcomes

The aim of this study is to systematically analyze the dynamic pattern of preoperative and postoperative serum metabolites in colorectal cancer patients through metabolomics technology, and to screen the key metabolites with statistical differences and explore their correlation with surgical interventions by combining the baseline characteristics of the patients with the perioperative clinical data; to further reveal the impact of surgery on the body's metabolic remodeling pattern, and to explore the potential biomarkers and regulatory pathways, providing a theoretical basis for elucidating the metabolic mechanism. Investigaters will further reveal the impact of surgery on metabolic remodeling, explore potential biomarkers and regulatory pathways, provide theoretical basis for elucidating the metabolic mechanism, and evaluate its clinical translational value (e.g., postoperative monitoring, targeted intervention, etc.), so as to lay the foundation for the subsequent basic research and precise treatment strategies.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Colo-rectal Cancer Colonic Diseases Colonic Neoplasms Colorectal Neoplasms Digestive System Diseases Digestive System Neoplasms Gastrointestinal Diseases Gastrointestinal Neoplasms Intestinal Diseases Intestinal Neoplasms Neoplasms Neoplasms by Site Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Rectal Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

The First Affiliated Hospital of Chongqing Medical University

Chongqing, Chongqing Municipality, 400016, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Previous consent to participate;
Blood drawn and serum samples extracted and preserved both preoperatively and postoperatively;
Successful detection of metabolomics profiles from serum samples;
Acceptance of a standard radical colorectal cancer procedure;
Complete perioperative data available;
Adults with a pathologic diagnosis of colorectal cancer

Exclusion criteria

Have or have had a previous history of other malignancies;
Have a history of radiotherapy treatment;
Have a history of inflammatory bowel disease;
Have a familial history of genetic disorders;
Missing baseline data (age, BMI, gender, previous medical history, etc.);
Failed to leave the hospital earlier than medically indicated;
Failed to sign an informed consent form.

Treatment and study plan

serum metabolites

Other

serum metabolites before and after colorectal cancer surgery

Primary outcomes

postoperative complications

Time frame: From the first day of surgery to two months after surgery

Postoperative complications occurring within two months after surgery.

Sponsors and collaborators

Lead sponsor

Dong Peng

Other

Registry information

Official study title

Preoperative and Postoperative Changes in Serum Metabolome Dynamics in Colorectal Cancer Patients and Their Impact on Perioperative Clinical Outcomes

Important dates

Study start: 2023
Primary completion: 2025
Study completion: 2025
First posted: Jun 25, 2025
Registry last updated: Jun 25, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Active, Not Recruiting