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NCT Number: NCT03408379

Impact of Platelet Activation in Intracranial Aneurysm Rupture Risk - PLAQRAN

Sub arachnoid hemorrhage consecutive to intracranial aneurysm rupture is a devastating disease. Predictors of intracranial aneurysm rupture are limited and focus mainly on size and location. Platelet activation may have a deleterious role on aneurysm rupture. The assumption is that patients with ruptured intracranial aneurysm will present a higher rate of platelet activation compared to patients with non ruptured aneurysms.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

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Key information

Conditions

Intracranial Aneurysms Aneurysm Aneurysm, Ruptured Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Intracranial Aneurysm Intracranial Arterial Diseases Nervous System Diseases Ruptured Aneurysm Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Fondation Ophtalmologique A. de Rothschild

Paris, France, 75019

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient aged 18 and over
  • Patient presenting a single or multiple aneurysm
  • Patient presenting an intracranial aneurysm for which an intervention is planned (endovascular treatment or surgery) : elective intervention for an unruptured aneurysm or emergency surgery for a broken aneurysm

Exclusion criteria

  • Pregnant or breast feeding woman
  • Patient benefiting from legal protection measures

Treatment and study plan

Collection of blood sample in aneurysm

Other

In case of an endovascular treatment :

  • A blood sample (venous or arterial) of 10 ml will be taken at the beginning of the procedure, an intra aneurysmal blood sample (1mL) will be taken during the procedure and a blood sample (arterial) of 1 mL will be taken at the end of the procedure.
  • Iterative blood samples (arterial) of 10 mL will be taken at each follow up visit.

In case of a surgery treatment :

  • A blood sample (venous or arterial) of 10 ml will be taken at the beginning of the surgery.
  • A Tissue sample will be taken during the surgery
  • Iterative blood samples (arterial) of 10 mL will be taken at each follow up visit.

Primary outcomes

  1. Proportion of patients with platelet activation

    Time frame: in the 7 days before embolisation

    comparison of this proportion between patients with ruptured versus non ruptured intracranial aneurysm

Sponsors and collaborators

Lead sponsor

Fondation Ophtalmologique Adolphe de Rothschild

Network

Registry information

Acronym: PLAQRAN

Important dates

Study start
2017
Primary completion
2032
Study completion
2033
First posted
Jan 24, 2018
Registry last updated
Jan 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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