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Completed

NCT Number: NCT02742961

Impact of Peripheral Nerve Blockade on Outcomes After Total Knee Replacement

Pain is common after knee replacement surgery and can impact a variety of patient outcomes. Peripheral nerve blocks provide improved pain control and may improve function. However, their impact on other outcomes is poorly described. Therefore, this comparative effectiveness study will estimate the independent association between nerve blocks and health outcomes after knee replacement surgery.

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Key information

Conditions

Pain Arthritis Joint Diseases Musculoskeletal Diseases Neurologic Manifestations Osteoarthritis Pathological Conditions, Signs and Symptoms Rheumatic Diseases Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Ottawa Hospital Research Institute

Ottawa, Ontario, K1Y4E9, Canada

About this study

This retrospective, population-based cohort study will evaluate the comparative effectiveness of peripheral nerve blocks on patient and health system outcomes after elective total knee replacement surgery.

The investigators will develop a non-parsimonious propensity score to control for potential indication bias and confounding in this observational study. Using the propensity score the investigators will match patients who receive a peripheral nerve block to a patient who did not to estimate the independent association of peripheral nerve blocks with our study outcomes.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • first primary total knee replacement during the study period

Exclusion criteria

  • Revision arthroplasty

Treatment and study plan

Peripheral nerve block

Other

A physician billing code for deposition of a local anesthetic solution around an anatomically defined nerve or nerve plexus

Primary outcomes

  1. Hospital length of stay

    Time frame: Day of surgery to day of discharge, or up to 365 days, whichever comes first

    Determined from the Canadian Institute for Health Information Discharge Abstract Database record for the index hospitalization

Secondary outcomes

  1. Hospital readmission

    Time frame: The outcome ascertainment window starts on the day of discharge and extends up to 30 days after surgery. Any readmission in this time period will be considered an event.

    Determined from the Canadian Institute for Health Information Discharge Abstract Database through identification of a new record after discharge from the index hospitalization

  2. In-hospital fall

    Time frame: hospital admission

    Determined using validated International Classification of Diseases Tenth edition codes for falls from the index hospitalization Discharge Abstract Database record

  3. Emergency department visit

    Time frame: The outcome ascertainment window starts on the day of discharge and extends up to 30 days after surgery. Any emergency department visit in this time period will be considered an event.

    Defined as the creation of a record in the National Ambulatory Care Reporting System for an emergency department visit that occurs after discharge and before 30 days after discharge

Other outcomes

  1. All cause mortality

    Time frame: Day of surgery to 30 days after surgery

    Identified from the Registered Person's Database that records the date of death for all residents of Ontario

Sponsors and collaborators

Lead sponsor

Ottawa Hospital Research Institute

Other

Registry information

Important dates

Study start
2002
Primary completion
2014
Study completion
2014
First posted
Apr 19, 2016
Registry last updated
Apr 19, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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