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OpenTrials
Completed

NCT Number: NCT02900833

Impact of Neutrophil Activation in Acute Ischemic Stroke Patients Treated With Endovascular Therapy

Clinical and experimental data suggest that neutrophil activation and extravasation are deleterious in acute ischemic stroke (AIS) involving an increased risk of unfavorable outcome and hemorrhagic transformation (HT). However, clinical trials targeting neutrophil recruitment in AIS patients were negative. Recently, an experimental study has shown that neutrophil activation and transmigration begin immediately after the occlusion. Inhibition of neutrophil recruitment several hours after the start of ischemia appears therefore too late to have a clinical relevance.

The objective is to study the time dependent impact of neutrophils in AIS and the predominant mediators in each time point to identify the appropriate therapeutic target and time window.

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Key information

Conditions

Acute Stroke Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Nervous System Diseases Stroke Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Fondation Ophtalmologique Adolphe de Rothschild

Paris, 75019, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • age >= 18 years old
  • acute ischemic stroke secondary to a large vessel occlusion.
  • Patients hospitalized for endovascular therapy.

Exclusion criteria

  • Pregnant or breast feeding patient
  • patient under legal protection
  • Patient opposition to participate in this study

Treatment and study plan

Primary outcomes

  1. neutrophil counts

    Time frame: before recanalization

    Plasma neutrophil activation bio-markers

  2. neutrophil counts

    Time frame: immediately after recanalization

    Plasma neutrophil activation bio-markers

  3. neutrophil counts

    Time frame: 24 hours after recanalization

    Plasma neutrophil activation bio-markers

  4. neutrophil protease counts

    Time frame: before recanalization

  5. recanalization score

    Time frame: immediately after endovascular procedure

    Thrombolysis in Cerebral Infarction classification (TICI)

  6. acute ischemic stroke etiology

    Time frame: within 24 hours after endovascular procedure

    as defined by the Trial of Danaparoid (ORG10172) in Acute Stroke Treatment (TOAST classification)

  7. severity of neurologic symptoms

    Time frame: baseline

    National Institutes of Health Stroke Scale (NIHSS)

  8. disruption of the blood-brain-barrier

    Time frame: within 24 hours after endovascular procedure

    diagnosis on cerebral Computerized Tomography

  9. brain haemorrhage

    Time frame: 24 hours after endovascular procedure

    National Institutes of Health Stroke Scale (NIHSS)

  10. Recovery of motor function after stroke

    Time frame: 3 months

    modified Rankin scale

  11. mortality

    Time frame: 3 months

  12. adhesion molecules counts

    Time frame: before recanalization

  13. adhesion molecules counts

    Time frame: immediately after recanalization

  14. adhesion molecules counts

    Time frame: 24 hours after recanalization

  15. free plasma DNA counts

    Time frame: before recanalization

  16. free plasma DNA counts

    Time frame: immediately after recanalization

  17. free plasma DNA counts

    Time frame: 24 hours after recanalization

  18. neutrophil protease counts

    Time frame: immediately after recanalization

  19. neutrophil protease counts

    Time frame: 24 hours after recanalization

Sponsors and collaborators

Lead sponsor

Fondation Ophtalmologique Adolphe de Rothschild

Network

Registry information

Official study title

Neutrophil Activation in Acute Ischemic Stroke Patients Treated With Endovascular Therapy

Acronym: NEUTROSTROKE

Important dates

Study start
2016
Primary completion
2022
Study completion
2026
First posted
Sep 14, 2016
Registry last updated
Jul 6, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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