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OpenTrials
Completed

NCT Number: NCT00851708

Impact of N-Acetylcysteine on Oxidative Stress and Renal Function in Deceased Kidney Transplant Recipients

The aim of this interventional, prospective, randomized clinical trial is to evaluate the impact of the antioxidant N-acetylcysteine on oxidative stress in the first seven postoperative days and on renal function in the first three postoperative months in deceased kidney transplantation.

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Key information

Conditions

Deceased Kidney Transplantation

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Clinics Hospital, University of Sao Paulo, Medical School

São Paulo, 05403-001, Brazil

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • First transplant
  • Deceased kidney transplant

Exclusion criteria

  • postoperative recovery at critical care unit
  • illicit drug addiction
  • psychiatric disorders

Treatment and study plan

N-acetylcysteine

Drug

600 mg bid orally from day 1 to 7 postoperative

Primary outcomes

  1. Tiobarbituric acid reactive species measures

    Time frame: First seven postoperative days

Secondary outcomes

  1. Serum creatinine

    Time frame: 7, 15, 30, 60, 90 postoperative day

Sponsors and collaborators

Lead sponsor

University of Sao Paulo

Other

Collaborators

  • Fundação de Amparo à Pesquisa do Estado de São Paulo

Registry information

Official study title

Oxidative Stress and Postoperatory Renal Function in Deceased Kidney Transplantation

Important dates

First posted
Feb 26, 2009
Registry last updated
Mar 2, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.