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OpenTrials
Completed

NCT Number: NCT02187965

Impact of Muscle Fat Accumulation on the Genomic Profile of Skeletal Muscle in Older Adults

Subjects were asked to come to the Purdue facilities after an overnight fast on 2 different testing days for 2.5 hours each day. On one day the subjects participated in blood pressure and body weight measurements as well as a muscle biopsy from the thigh. On the second day the subjects underwent an MRI and MRS scan of the thigh and calf.

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Key information

Conditions

Intermuscular Adipose Tissue Quantification

Age range

60 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Purdue University

West Lafayette, Indiana, 47906, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 60-80 years old, men and women, normal body weight or obese,

Exclusion criteria

  • Certain medical conditions could have placed them at risk

Treatment and study plan

Primary outcomes

  1. MRI

    Time frame: 1 day

    To determine the within day reproducibility of MRI scans for intermuscular adipose tissue (IMAT) quantification in older men and women.

Secondary outcomes

  1. genomic profile

    Time frame: 1 day

    To examine the influence of IMAT accumulation on the genomic profile of skeletal muscle of normal weight or obese adults.

Sponsors and collaborators

Lead sponsor

Purdue University

Other

Registry information

Important dates

Study start
2011
Primary completion
2012
Study completion
2012
First posted
Jul 11, 2014
Registry last updated
Jul 11, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.