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NCT Number: NCT05875623

Impact of Medications Review on Potentially Inappropriate Medications and Clinical Outcomes Among Hospitalized Older Adults

The goal of this randomized controlled trial is to assess the effectiveness of a pharmacist-led medication review using the locally developed Malaysian Potentially Inappropriate Prescribing Screening tool in Older Adults (MALPIP), an explicit criteria in hospitalized older adults. The main questions it aims to answer are:

1. The effectiveness of the intervention in reducing the number of PIMs and chronic medications after discharge 2. The impact of the intervention on quality of life, falls events, emergency department visits, readmissions and survivals

Researchers will compare the control group to see if there is corresponding changes to the outcomes specified above.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

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Key information

Conditions

Deprescriptions Aged Inappropriate Prescribing Polypharmacy Potentially Inappropriate Medications

Age range

60 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Shaun Lee

Subang Jaya, Selangor, 47500, Malaysia

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients aged 60 years and above
  • Taking more than five regular drugs
  • Having at least one chronic medical condition
  • Ability to understand and speak Malay, English, or Mandarin language

Exclusion criteria

  • Admitted for end-of-life care
  • Diagnosed with terminal illness
  • Diagnosed with active cancer
  • Participated in another drug trial
  • Refused or unable to give consent
  • Visited the Emergency Department without admission to ward
  • Readmitted and have been previously enrolled in the trial

Treatment and study plan

MALPIP criteria

Other

In the intervention group, the clinical pharmacist will apply the MALPIP criteria on all the admission and discharge medications. The intervention will consist of 4 steps: i) pharmacist review using MALPIP criteria to detect PIM, ii) discussion with doctors for deprescribing decision iii) discussion with patients and documentation of shared decision iv) follow up patients

Primary outcomes

  1. Number of potentially inappropriate medications

    Time frame: Admission up to 18 months

  2. Number of chronic medications

    Time frame: Admission up to 18 months

Sponsors and collaborators

Lead sponsor

Monash University

Other

Collaborators

  • Hospital Raja Permaisuri Bainun

Registry information

Official study title

Impact of Medications Review on Potentially Inappropriate Medications and Clinical Outcomes Among Hospitalized Older Adults: A Randomized Controlled Trial (REVMED RCT) Protocol

Important dates

Study start
2023
Primary completion
2025
Study completion
2025
First posted
May 25, 2023
Registry last updated
May 8, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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